National Institutes of Health · Department of Health and Human Services
Mechanistic Evaluation of Therapeutic Targets derived from Treatable Traits to Improve CNS Outcomes in People with HIV (R21/R33 Clinical Trial Not Allowed)
Key facts
- Deadline
- Due Oct 28, 2027 · 386 days left
- Award size
- Not specified — see notice
- Cost share / match ?
- Not required · Work out your budget and match
- Who can apply
- Larger business, Private college or university, Small business, Nonprofit without 501(c)(3), City or town government, Other (see eligibility), County government, State government, Tribal government, Special district (utility, fire, etc.), Tribal organization, Nonprofit with 501(c)(3), Public college or university, School district
- Where
- Anywhere in the U.S., including Tennessee
Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Grant-ready checklist
How this fits you
- Available in Tennessee (nationwide program)
- No cost share required
- Past Tennessee awards on file: 113
Tell us who you are to see whether you're eligible.
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Official notice: https://simpler.grants.gov/opportunity/48bf4c5c-b6b3-4092-bbf4-32c3708800e1 · Printed from grantme.click/grants/e697b7dd-4ef4-4367-a1f5-71e13b106b09
Read the official notice View on Grants.gov Add deadline to my calendar Sign in to save
About this grant
The purpose of this notice of funding opportunity (NOFO) is to identify modifiable mechanisms and therapeutic targets to address central nervous system (CNS) complications associated with human immunodeficiency virus (HIV). The initiative supports a phased research approach beginning with the identification of patient phenotypes characterized by convergent pathophysiological features, followed by the discovery and experimental validation of molecular mechanisms using innovative in-vitro and in-vivo models. The goal of this NOFO is to advance therapeutic target, and intervention discovery to address the multifactorial and heterogeneous nature of HIV-associated CNS dysfunction.
Eligibility (from the notice)
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Should we apply? (2-minute check) Ask a partner for a letter
Your schedule, working back from the deadline
- Oct7
Check that your SAM.gov registration is active (or start it now)
Grants.gov: allow up to 10 business days for SAM registration, weeks or months if information isn't verified. It must be renewed every year. Grants.gov - Oct7
Ask partners for letters of support or commitment
Suggested: partners need time to write and sign letters. - Oct21
Finish a complete draft for a final review
University grant offices require final versions about 5 business days before the sponsor deadline. Emory Office of Sponsored Programs - Oct26
Submit
Grants.gov: submit at least 24–48 hours before the deadline: uploads fail, systems slow down, errors need fixing. Grants.gov blog - Oct28
Deadline
From the funder.
Save this grant to put these dates in your tracker and private calendar.
Who in Tennessee has won this program
60 awards to Tennessee recipients in 4 counties since 1989. Largest shown:
| Recipient | Where | Amount | FY |
|---|---|---|---|
| Vanderbilt University | Nashville, Davidson County | $8.7M | 2001 |
| Vanderbilt University | Nashville, Davidson County | $8.7M | 2006 |
| Vanderbilt University | Nashville, Davidson County | $8.1M | 2005 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $7.6M | 2012 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $7.4M | 2020 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | $7.1M | 2017 |
| Vanderbilt University | Nashville, Davidson County | $6.8M | 2004 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $6.4M | 2005 |
| Vanderbilt University | Nashville, Davidson County | $5.4M | 2009 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $5.3M | 2016 |
| University Of Tennessee | Memphis, Shelby County | $5.3M | 2002 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $5.3M | 2020 |
Source: USAspending.gov. Past awards show who this program funds; they don't guarantee future awards.
Tennessee groups that got this money through a state agency or another grantee
This federal money also reaches local groups as subawards. 53 subawards on file. Largest shown:
| Recipient | Where | Through | Amount | FY |
|---|---|---|---|---|
| Vanderbilt University | Nashville, Davidson County | Yale Univ | $1.6M | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | The Trustees of Princeton University | $1.6M | 2023 |
| Vanderbilt University | Nashville, Davidson County | The Pennsylvania State University | $1.1M | 2026 |
| Vanderbilt University Medical Center | Nashville, Davidson County | The General Hospital Corporation | $839K | 2026 |
| Vanderbilt University | Nashville, Davidson County | The Pennsylvania State University | $756K | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Icahn School of Medicine At Mount Sinai | $734K | 2025 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | University of Miami | $654K | 2023 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | University of Miami | $588K | 2025 |
| Vanderbilt University | Nashville, Davidson County | Vanderbilt University Medical Center | $560K | 2023 |
| University Of Tennessee | Memphis, Shelby County | University of Puerto Rico | $553K | 2026 |
| Vanderbilt University Medical Center | Nashville, Davidson County | The University of Iowa | $538K | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Icahn School of Medicine At Mount Sinai | $462K | 2024 |
Source: USAspending.gov subaward reports (prime recipients report subawards of $30,000 or more).
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Matching requirements
This program has no statutory formula.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.
Examples of funded projects
Not Applicable.