National Institutes of Health · Department of Health and Human Services
Bioengineering Research Grants (BRG) (R01 Clinical Trial Optional)
Key facts
- Deadline
- Due Jul 5, 2029 · 1002 days left
- Award size
- Up to $500K
- Match ?
- Not required · Work out your budget and match
- Who can apply
- County government, Larger business, Special district (utility, fire, etc.), School district, Tribal government, Nonprofit with 501(c)(3), State government, Public college or university, Tribal organization, Nonprofit without 501(c)(3), City or town government, Small business, Private college or university, and others named in the official notice
- Where
- Anywhere in the U.S., including Tennessee
Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Get-ready checklist
How this fits you
- Available in Rhea County (nationwide program)
- No match required
- Past Tennessee awards on file: 731
Tell us who you are to see whether you're eligible.
Official notice: https://simpler.grants.gov/opportunity/4fa4f79e-d43d-42c9-9269-f219c7bc09df · Printed from grantme.click/grants/0af667b8-0147-44d7-9afc-84109260bfb6
View on Grants.gov Add deadline to my calendar
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About this grant
This Notice of Funding Opportunity (NOFO) encourages collaborations between the life and physical sciences that: 1) apply a multidisciplinary bioengineering approach to the solution of a biomedical problem; and 2) integrate, optimize, validate, translate or otherwise accelerate the adoption of promising tools, methods, and techniques for a specific research or clinical problem in basic, translational, or clinical science and practice. An application may propose design-directed, developmental, discovery-driven, or hypothesis-driven research and is appropriate for small teams applying an integrative approach to increase our understanding of and solve problems in biological, clinical, or translational science. This NOFO will support clinical trials that test functionality or validate performance in the chosen setting. This NOFO is not intended to support conventional clinical trials that lack translation as the primary motivation. Applications that propose phase III clinical trials in any area of research are not sought by and will not be supported through this NOFO. This NOFO does not support commercial production.
Who can apply, from the official notice
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Your schedule, working back from the deadline
- Oct7
Check that your SAM.gov registration is active (or start it now)
Grants.gov: allow up to 10 business days for SAM registration, weeks or months if information isn't verified. It must be renewed every year. Grants.gov - Jun14
Ask partners for letters of support or commitment
Suggested: partners need about three weeks to write and sign letters. - Jun28
Finish a complete draft for a final review
Suggested: leave about a week for someone else to read the draft. - Jul3
Submit
Grants.gov: submit at least 24–48 hours before the deadline: uploads fail, systems slow down, errors need fixing. Grants.gov blog - Jul5
Deadline
From the funder.
Save this grant to put these dates in My grants and your private calendar.
Writing the need statement? Rhea County facts with citations.
Who in Tennessee has won this program
173 awards to Tennessee groups in 4 counties since 1977 · 0 in Rhea County. Largest shown:
| Past winner | Where | Amount | Fiscal year |
|---|---|---|---|
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | $81.5M | 1993 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | $41.4M | 1999 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | $31.4M | 2003 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $25.8M | 2009 |
| St. Jude Children's Research Hospital, Inc. | Memphis, Shelby County | $14.7M spent that year | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $14.4M spent that year | 2025 |
| St. Jude Children's Research Hospital, Inc. | Memphis, Shelby County | $14.2M spent that year | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $14M | 2016 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $14M | 1997 |
| Vanderbilt University | Nashville, Davidson County | $14M | 1997 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $12.8M | 2010 |
| Vanderbilt University | Nashville, Davidson County | $12.7M | 2021 |
Source: USAspending.gov, Federal Audit Clearinghouse. Past awards show who this program funds. They don't guarantee future awards.
Tennessee groups that got this money through a state agency or another organization
This federal money also reaches local groups as pass-through grants. 558 pass-through grants on file · 0 in Rhea County. Largest shown:
| Past winner | Where | Through | Amount | Fiscal year |
|---|---|---|---|---|
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | University of Southern California | $2.8M | 2023 |
| Vanderbilt University | Nashville, Davidson County | Vanderbilt University Medical Center | $2.5M | 2023 |
| Vanderbilt University | Nashville, Davidson County | Yale Univ | $1.6M | 2023 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | The Johns Hopkins University | $1.4M | 2025 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | Baylor College of Medicine | $1.4M | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Health Research, Inc. | $1.3M | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | University of California, San Diego | $1.3M | 2024 |
| Vanderbilt University | Nashville, Davidson County | Vanderbilt University Medical Center | $1.1M | 2023 |
| St. Jude Children's Research Hospital, Inc. | Memphis, Shelby County | Public Health Institute | $1.1M spent that year | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Vanderbilt University | $1.1M spent that year | 2025 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | Ohio State University, the | $1M | 2023 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | Washington University, the | $1M | 2024 |
Source: USAspending.gov pass-through reports (the first recipient reports each one of $30,000 or more).
About the federal program
Cancer Cause and Prevention Research
Program number 93.393 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Cooperative agreement (a grant with close agency involvement), project grant
How applications are judged
The major elements in evaluating proposals include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; 2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific...
Match
None required (federal program listing).
About the federal program
Cancer Detection and Diagnosis Research
Program number 93.394 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Cooperative agreement (a grant with close agency involvement), project grant
How applications are judged
The major elements in evaluating proposals include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; 2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific...
Match
None required (federal program listing).
About the federal program
Cancer Treatment Research
Program number 93.395 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Cooperative agreement (a grant with close agency involvement), project grant
How applications are judged
The major elements in evaluating applications include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the...
Match
None required (federal program listing).
About the federal program
Cancer Biology Research
Program number 93.396 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Cooperative agreement (a grant with close agency involvement), project grant
How applications are judged
The major elements in evaluating applications include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following will be considered in making funding decisions: 1) Scientific and technical merit of the proposed project as determined by scientific peer review; 2) Availability of funds; and 3) Relevance of the proposed project to program priorities.
Match
None required (federal program listing).
About the federal program
Cancer Control, also called “Cancer Control Grants”
Program number 93.399 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Project grant
How applications are judged
The major elements in evaluating proposals include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives.
Match
None required (federal program listing).
About the federal program
Extramural Research Programs in the Neurosciences and Neurological Disorders
Program number 93.853 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Project grant
How applications are judged
The major elements in evaluating proposals include assessments of: (1) the scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) the soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) the degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific...
Match
None required (federal program listing).
About the federal program
Child Health and Human Development Extramural Research, also called “Child Health and Human Development”
Program number 93.865 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Project grant
How applications are judged
The major elements in evaluating proposals include assessments of the significance of the proposed research; approach; innovation; investigators; and environment. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific and technical merit of the proposed approach for achieving the Phase II objectives; (3) the qualifications of the proposed principal investigator, supporting staff, and consultants; (4) the technological innovation originality, or societal importance of the proposed research; (5) the potential of the proposed research for commercial application; (6) the reasonableness of the budget...
Match
None required (federal program listing).
Examples of funded projects
Fiscal year 2025: The following is a tiny sample of fiscal year 2025 NICHD funded grants within the discretionary award class type. 1) Understanding the role of early life social determinants and sex-specific pubertal pathways in the development of adolescent chronic pain. 2) Improving In Vitro Fertilization Success through Multiplexed Optical Metabolic Imaging. 3) Genetic Studies of Large Palindromes. 4) A Safe, Fast, and Cost-Effective System for Tissue Removal in Laparoscopic Hysterectomy and Other Minimally Invasive Surgery.
The following is a tiny sample of fiscal year 2025 NICHD funded grants within the cooperative agreement award class type. 1) Study of Treatment and Reproductive outcomes. 2) Pediatric HIV/AIDS Cohort Study (PHACS): Research on Immune Aging, Sexual and Reproductive Health, and Perinatal Acquisition: Elucidating Relationships in HIV (RISE). 3) Pelvic Floor Disorders Network Data Coordinating Center. 4) NICHD Maternal-Fetal Medicine Units (MFMU) Network: Data Coordinating Center.
Fiscal year 2026: The following is a tiny sample of fiscal year 2026 NICHD funded grants within the discretionary award class type. 1) Placental Proteins and Prematurity. 2) In...
About the federal program
Vision Research, also called “NEI”
Program number 93.867 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Project grant
How applications are judged
The following consideration will be used in determining projects to be funded: (1) Technical merit of the proposed project; (2) Availability of funds; and (3) Relevance to program priorities.
Match
None required (federal program listing).