21st Century Cures Act - Precision Medicine Initiative

To provide support for initiatives funded under the 21st Century Cures Act, the All of Us Research Program will gather data from one million or more diverse people living in the United States to accelerate research and improve health. By taking into account individual differences in lifestyle, environment, and biology, researchers will uncover paths toward delivering precision medicine.

The awardee will be a university, college, hospital, public agency, nonprofit research institution or for-profit organization that applies and receives an award for support of research by a named principal investigator. To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council.

For grants and cooperative agreements, funding decisions are based on scientific merit (42 CFR 52h) and program relevance. Scientific merit review encompasses: the peer review criteria detailed in the specific funding announcement, as well as the significance, approach, and innovation of the proposed research; the competency of the principal investigator; the adequacy of the resources and environment; the proposed budget and requested period of support; and, where applicable, the adequacy of the measures for protecting against adverse effects upon humans, animals, or the environment. For Other Transactions the Research Opportunity Announcement (ROA) will detail the review process for each initiative.