National Institutes of Health · Department of Health and Human Services
Full-Scale Hybrid Effectiveness-Implementation Trials for Mental Health Interventions (R01 - Clinical Trial Required)
Key facts
- Deadline
- Due Oct 15, 2027 · 373 days left
- Award size
- Not specified — see notice
- Cost share / match ?
- Not required · Work out your budget and match
- Who can apply
- Public college or university, Nonprofit without 501(c)(3), Small business, County government, Other (see eligibility), Special district (utility, fire, etc.), Tribal government, School district, Larger business, Tribal organization, Private college or university, City or town government, Nonprofit with 501(c)(3), State government
- Where
- Anywhere in the U.S., including Tennessee
Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Grant-ready checklist
How this fits you
- Available in Tennessee (nationwide program)
- No cost share required
- Past Tennessee awards on file: 43
Tell us who you are to see whether you're eligible.
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Official notice: https://simpler.grants.gov/opportunity/0c04af5a-83ce-4fe5-a8fb-a7399f78e6d6 · Printed from grantme.click/grants/f803b07e-2aba-40df-8788-592ed7037f27
Read the official notice View on Grants.gov Add deadline to my calendar Sign in to save
About this grant
Clinical Trials to Test the Effectiveness of Treatment, Preventive, and Services Interventions (R01 Clinical Trial Required). This NOFO is a key element of NIMHs set of NOFOs to support clinical trials research across the intervention development and testing pipeline. The NOFO supports (1) clinical trials to test the effectiveness of optimized therapeutic and preventive interventions for use in community and practice settings; and (2) clinical trials to evaluate the effectiveness of patient-, provider-, organizational-, or systems-level services interventions to improve access, continuity, quality, equity, and/or value of mental health services. This NOFO is intended to support trials that: address a significant problem, such that the findings have potential to inform practice; are adequately powered to definitively answer the primary research question(s), with well-justified hypotheses supported by pilot data; and are designed to examine questions regarding mediators and moderators of effects. Consistent with the NIMH experimental therapeutics approach, this NOFO is intended to support effectiveness trials that explicitly address whether the intervention engages the target(s)/mechanism(s) presumed to underlie the intervention effects (i.e., the mechanism(s) that accounts for changes in clinical/functional outcomes, changes in provider behavior, improved access or continuity of services, etc.). The collaborative R01 mechanism provides support for multisite trials when two or more sites are necessary for completion of the trial (e.g., to increase sample size, accelerate recruitment, or increase sample diversity and representation).
Eligibility (from the notice)
Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Should we apply? (2-minute check) Ask a partner for a letter
Your schedule, working back from the deadline
- Oct7
Check that your SAM.gov registration is active (or start it now)
Grants.gov: allow up to 10 business days for SAM registration, weeks or months if information isn't verified. It must be renewed every year. Grants.gov - Sep24
Ask partners for letters of support or commitment
Suggested: partners need about three weeks to write and sign letters. - Oct8
Finish a complete draft for a final review
Suggested: leave about a week for someone else to read the draft. - Oct13
Submit
Grants.gov: submit at least 24–48 hours before the deadline: uploads fail, systems slow down, errors need fixing. Grants.gov blog - Oct15
Deadline
From the funder.
Save this grant to put these dates in your tracker and private calendar.
Who in Tennessee has won this program
22 awards to Tennessee recipients in 2 counties since 1989. Largest shown:
| Recipient | Where | Amount | FY |
|---|---|---|---|
| Vanderbilt University | Nashville, Davidson County | $8.7M | 2001 |
| Vanderbilt University | Nashville, Davidson County | $8.7M | 2006 |
| Vanderbilt University | Nashville, Davidson County | $8.1M | 2005 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $7.4M | 2020 |
| Vanderbilt University | Nashville, Davidson County | $6.8M | 2004 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $6.4M | 2005 |
| Vanderbilt University | Nashville, Davidson County | $5.4M | 2009 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $5.3M | 2020 |
| Vanderbilt University | Nashville, Davidson County | $5M | 2002 |
| Vanderbilt University | Nashville, Davidson County | $4.5M | 1989 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.3M | 2019 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.1M | 2014 |
Source: USAspending.gov. Past awards show who this program funds; they don't guarantee future awards.
Tennessee groups that got this money through a state agency or another grantee
This federal money also reaches local groups as subawards. 21 subawards on file. Largest shown:
| Recipient | Where | Through | Amount | FY |
|---|---|---|---|---|
| Vanderbilt University Medical Center | Nashville, Davidson County | The Trustees of Princeton University | $1.6M | 2023 |
| Vanderbilt University | Nashville, Davidson County | The Pennsylvania State University | $1.1M | 2026 |
| Vanderbilt University Medical Center | Nashville, Davidson County | The General Hospital Corporation | $839K | 2026 |
| Vanderbilt University | Nashville, Davidson County | The Pennsylvania State University | $756K | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Icahn School of Medicine At Mount Sinai | $734K | 2025 |
| Vanderbilt University | Nashville, Davidson County | Vanderbilt University Medical Center | $560K | 2023 |
| University Of Tennessee | Memphis, Shelby County | University of Puerto Rico | $553K | 2026 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Icahn School of Medicine At Mount Sinai | $462K | 2024 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Vanderbilt University | $385K | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Vanderbilt University | $359K | 2024 |
| Vanderbilt University | Nashville, Davidson County | The Trustees of Columbia University in the City of New York | $346K | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Vanderbilt University | $339K | 2026 |
Source: USAspending.gov subaward reports (prime recipients report subawards of $30,000 or more).
About the program (93.242)
Mental Health Research Grants
How applications are judged
The following consideration will be used in determining projects to be funded: (1) Technical merit of the proposed project as determined by peer review; (2) Availability of funds; and (3) Relevance to program priorities.
Matching requirements
This program has no statutory formula.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.
Examples of funded projects
Not Applicable.