National Institutes of Health · Department of Health and Human Services
Pilot Hybrid Effectiveness-Implementation Trials for Mental Health Interventions (R01 Clinical Trial Required)
Key facts
- Deadline
- Due Oct 15, 2027 · 373 days left
- Award size
- Not stated: see the official notice
- Match ?
- Not required · Work out your budget and match
- Who can apply
- County government, City or town government, Special district (utility, fire, etc.), Private college or university, School district, Public college or university, Tribal government, Larger business, State government, Nonprofit without 501(c)(3), Tribal organization, Nonprofit with 501(c)(3), Small business, and others named in the official notice
- Where
- Anywhere in the U.S., including Tennessee
Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Get-ready checklist
How this fits you
- Available in Tennessee (nationwide program)
- No match required
- Past Tennessee awards on file: 43
Tell us who you are to see whether you're eligible.
Official notice: https://simpler.grants.gov/opportunity/b8708107-b111-4a75-a6b2-7189a2e15538 · Printed from grantme.click/grants/ef6aacb9-6066-4580-8d37-6c4d841ec94a
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About this grant
Pilot Effectiveness Trials for Treatment, Preventive and Services Interventions (R01 Clinical Trial Required). As part of NIMH's clinical trials pipeline NOFOs, this announcement encourages pilot effectiveness studies focused on 1) optimizing the effectiveness of preventive and therapeutic interventions with previously demonstrated efficacy, for use with broader target populations or for use in community practice settings, and 2) developing and preliminary testing innovative services interventions. Consistent with the NIMH experimental therapeutics approach, this NOFO is intended to support pilot studies of intervention effectiveness or service delivery approaches that explicitly address whether the intervention engages the target(s)/mechanism(s) presumed to underlie the intervention effects (i.e., the mechanism(s) that accounts for changes in clinical/functional outcomes, changes in provider behavior, improved access or continuity of services, etc.).
Who can apply, from the official notice
Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Your schedule, working back from the deadline
- Oct7
Check that your SAM.gov registration is active (or start it now)
Grants.gov: allow up to 10 business days for SAM registration, weeks or months if information isn't verified. It must be renewed every year. Grants.gov - Sep24
Ask partners for letters of support or commitment
Suggested: partners need about three weeks to write and sign letters. - Oct8
Finish a complete draft for a final review
Suggested: leave about a week for someone else to read the draft. - Oct13
Submit
Grants.gov: submit at least 24–48 hours before the deadline: uploads fail, systems slow down, errors need fixing. Grants.gov blog - Oct15
Deadline
From the funder.
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Who in Tennessee has won this program
22 awards to Tennessee groups in 2 counties since 1989. Largest shown:
| Past winner | Where | Amount | Fiscal year |
|---|---|---|---|
| Vanderbilt University | Nashville, Davidson County | $8.7M | 2001 |
| Vanderbilt University | Nashville, Davidson County | $8.7M | 2006 |
| Vanderbilt University | Nashville, Davidson County | $8.1M | 2005 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $7.4M | 2020 |
| Vanderbilt University | Nashville, Davidson County | $6.8M | 2004 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $6.4M | 2005 |
| Vanderbilt University | Nashville, Davidson County | $5.4M | 2009 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $5.3M | 2020 |
| Vanderbilt University | Nashville, Davidson County | $5M | 2002 |
| Vanderbilt University | Nashville, Davidson County | $4.5M | 1989 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.3M | 2019 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.1M | 2014 |
Source: USAspending.gov. Past awards show who this program funds. They don't guarantee future awards.
Tennessee groups that got this money through a state agency or another organization
This federal money also reaches local groups as pass-through grants. 21 pass-through grants on file. Largest shown:
| Past winner | Where | Through | Amount | Fiscal year |
|---|---|---|---|---|
| Vanderbilt University Medical Center | Nashville, Davidson County | The Trustees of Princeton University | $1.6M | 2023 |
| Vanderbilt University | Nashville, Davidson County | The Pennsylvania State University | $1.1M | 2026 |
| Vanderbilt University Medical Center | Nashville, Davidson County | The General Hospital Corporation | $839K | 2026 |
| Vanderbilt University | Nashville, Davidson County | The Pennsylvania State University | $756K | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Icahn School of Medicine at Mount Sinai | $734K | 2025 |
| Vanderbilt University | Nashville, Davidson County | Vanderbilt University Medical Center | $560K | 2023 |
| University of Tennessee | Memphis, Shelby County | University of Puerto Rico | $553K | 2026 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Icahn School of Medicine at Mount Sinai | $462K | 2024 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Vanderbilt University | $385K | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Vanderbilt University | $359K | 2024 |
| Vanderbilt University | Nashville, Davidson County | The Trustees of Columbia University in the City of New York | $346K | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Vanderbilt University | $339K | 2026 |
Source: USAspending.gov pass-through reports (the first recipient reports each one of $30,000 or more).
About the federal program
Mental Health Research Grants
Program number 93.242 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Cooperative agreement (a grant with close agency involvement), project grant, training
How applications are judged
The following consideration will be used in determining projects to be funded: (1) Technical merit of the proposed project as determined by peer review; (2) Availability of funds; and (3) Relevance to program priorities.
Match
None required (federal program listing).