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U.S. National Science Foundation

Infrastructure Innovation for Biological Research (Innovation)

Open

In short: U.S. National Science Foundation expects to make 40 awards of $300,000 to $800,000.

Key facts

Deadline
Accepts applications through Oct 7, 2076. Rounds may close sooner: check the notice
The funder says: “Proposals accepted anytime”
Award size
$300K – $800K
Total available
$18M · about 40 awards
Match ?
Not required · Work out your budget and match
Who can apply
Set by the official notice: see Who can apply below
Where
Anywhere in the U.S., including Tennessee

Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Get-ready checklist

How this fits you

  • Available in Blount County (nationwide program)
  • No match required
  • Past Tennessee awards on file: 74

Tell us who you are to see whether you're eligible.

About this grant

The Infrastructure Innovation for Biological Research Program (Innovation) supports research to design novel or greatly improved research tools and methods that advance contemporary biology in any research area supported by the Directorate for Biological Sciences at NSF. The Innovation Program focuses on research infrastructure that is broadly applicable to researchers in three programmatic areas: Bioinformatics, Instrumentation, and Research Methods. Infrastructure supported by this program is expected to advance biological understanding by improving scientists’ abilities to manipulate, control, analyze, or measure critical aspects of biological systems, which can be essential for addressing important fundamental research questions. Proposals submitted to these programmatic areas can do one of three things to advance or transform research in biology: develop novel infrastructure, significantly redesign existing infrastructure, or adapt existing infrastructure in novel ways. Projects are expected to have a significant application to one or more biological science questions and have the potential to be used by a community of researchers beyond a single research team. Please refer to the descriptions of individual programmatic areas for detailed guidance on what is supported through this solicitation (see links below).

Who can apply, from the official notice

*Who May Submit Proposals: Proposals may only be submitted by the following: -Non-profit, non-academic organizations: Independent museums, observatories, research laboratories, professional societies and similar organizations located in the U.S. that are directly associated with educational or research activities. -Institutions of Higher Education (IHEs): Two- and four-year IHEs (including community colleges) accredited in, and having a campus located in the US, acting on behalf of their faculty members. Special Instructions for International Branch Campuses of US IHEs: If the proposal includes funding to be provided to an international branch campus of a US institution of higher education (including through use of sub-awards and consultant arrangements), the proposer must explain the benefit(s) to the project of performance at the international branch campus, and justify why the project activities cannot be performed at the US campus. *Who May Serve as PI: There are no restrictions or limits.

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Ask a partner for a letter

Your schedule, working back from the deadline

  1. Oct9
    Check that your SAM.gov registration is active (or start it now)
    Grants.gov: allow up to 10 business days for SAM registration, weeks or months if information isn't verified. It must be renewed every year. Grants.gov
  2. Sep16
    Ask partners for letters of support or commitment
    Suggested: partners need about three weeks to write and sign letters.
  3. Sep30
    Finish a complete draft for a final review
    Suggested: leave about a week for someone else to read the draft.
  4. Oct5
    Submit
    Grants.gov: submit at least 24–48 hours before the deadline: uploads fail, systems slow down, errors need fixing. Grants.gov blog
  5. Oct7
    Deadline
    From the funder.

Save this grant to put these dates in My grants and your private calendar.

Writing the need statement? Blount County facts with citations.

Who in Tennessee has won this program

30 awards to Tennessee groups in 3 counties since 2018 · 0 in Blount County. Largest shown:

Past Tennessee winners
Past winnerWhereAmountFiscal year
State of TennesseeNashville$7.3M spent that year2025
Vanderbilt UniversityNashville, Davidson County$3M2024
Vanderbilt UniversityNashville$2.8M spent that year2025
University of TennesseeKnoxville, Knox County$2.5M2018
University of TennesseeKnoxville, Knox County$2.3M2022
University of TennesseeKnoxville, Knox County$1.7M2024
Vanderbilt UniversityNashville, Davidson County$1.5M2024
University of TennesseeKnoxville, Knox County$1.5M2020
University of MemphisMemphis, Shelby County$1.5M2025
University of TennesseeKnoxville, Knox County$1.5M2027
University of TennesseeKnoxville, Knox County$1.4M2021
University of TennesseeKnoxville, Knox County$1.4M2021

Source: Federal Audit Clearinghouse; USAspending.gov. Past awards show who this program funds. They don't guarantee future awards.

Tennessee groups that got this money through a state agency or another organization

This federal money also reaches local groups as pass-through grants. 44 pass-through grants on file · 0 in Blount County. Largest shown:

Tennessee pass-through grant winners
Past winnerWhereThroughAmountFiscal year
Meharry Medical CollegeNashville, Davidson CountyVirginia Polytechnic Institute & State University$767K2025
University of TennesseeMemphis, Shelby CountyColorado State University$386K2023
St Jude Children's Research Hospital IncMemphis, Shelby CountyUniversity of Missouri System$291K2023
University of TennesseeKnoxville, Knox CountyEmory University$288K2023
Vanderbilt UniversityNashville, Davidson CountyUniversity of Pittsburgh - of the Commonwealth System of Higher Education$244K2023
Vanderbilt University Medical CenterNashville, Davidson CountyUniversity of Pittsburgh$234K spent that year2025
Vanderbilt University Medical CenterNashville, Davidson CountyUniversity of Pittsburgh - of the Commonwealth System of Higher Education$165K2024
University of TennesseeMemphis, Shelby CountyColorado State University$152K2025
St. Jude Children's Research Hospital, Inc.Memphis, Shelby CountyUniversity of Oklahoma$131K spent that year2025
University of MemphisMemphis, Shelby CountyTexas a&M Agrilife Research$125K2023
Ut-Battelle LLCOak RidgeCornell University$121K2025
Ut-Battelle LLCOak Ridge, Anderson CountyCornell University$118K2024

Source: USAspending.gov pass-through reports (the first recipient reports each one of $30,000 or more).

More from U.S. National Science Foundation

About the federal program

Biological Sciences, also called “(BIO)”
Program number 47.074 (the federal Assistance Listing number) · National Science Foundation · Project grant

Match

None required (federal program listing).

This program on SAM.gov

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Source: Federal grants from Grants.gov · the official federal record. Last checked by GrantMe Oct 9, 2026.

Reference numbers: official notice number 23-578 · program number 47.074