National Institutes of Health · Department of Health and Human Services
Advancing Real-World Effectiveness Evidence for Rapid-Acting Psychotropic Interventional Drugs (RAPIDs)
Key facts
- Deadline
- Expected around Nov 13, 2026 (not yet confirmed)
- Award size
- Not specified — see notice
- Total available
- $20M · about 3 awards
- Cost share / match ?
- Not required
- Who can apply
- Larger business, Tribal organization, County government, Small business, City or town government, State government, School district, Public college or university, Other (see eligibility), Special district (utility, fire, etc.), Nonprofit without 501(c)(3), Nonprofit with 501(c)(3), Tribal government, Private college or university
- Where
- Anywhere in the U.S., including Tennessee
Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Grant-ready checklist
How this fits you
- Available in Tennessee (nationwide program)
- No cost share required
- Tennessee recipients since 2023: 22
Tell us who you are to see whether you're eligible.
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Official notice: https://simpler.grants.gov/opportunity/4baac4b9-a09e-4954-a1a4-bcb1a0bc5a9f · Printed from grantme.click/grants/e4d8d988-93eb-442e-9391-cef0b267df3e
Read the official notice View on Grants.gov Add dates to my calendar Sign in to save
About this grant
The National Institute of Mental Health (NIMH) intends to publish a Notice of Funding Opportunity (NOFO) to support the development of a research network to study rapid-acting psychotropic interventional drugs (RAPIDs), such as ketamine, esketamine, psilocybin, and other emerging treatments for serious mental illnesses.
Preliminary studies suggest that RAPIDs can produce clinically meaningful improvements in mental health outcomes, in some cases following a single dose. However, important questions remain regarding their effectiveness, safety, durability of benefit, and implementation in routine clinical practice. As these interventions move toward broader use, rigorous real-world evidence is needed to identify how RAPIDs can be delivered safely, effectively, and sustainably across diverse patients, providers, and health care settings.
The primary goal of this NOFO is to generate actionable evidence on the clinical effectiveness, safety, and implementation of RAPIDs. The resulting evidence from this study will help determine how RAPIDs can be safely and effectively integrated into clinical care and may inform future approaches to health care delivery.
Eligibility (from the notice)
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;
Who in Tennessee has won this program
22 awards to Tennessee recipients in 2 counties since federal FY2023. Largest shown:
| Recipient | Where | Amount | FY |
|---|---|---|---|
| Vanderbilt University | Nashville, Davidson County | $8.7M | 2001 |
| Vanderbilt University | Nashville, Davidson County | $8.7M | 2006 |
| Vanderbilt University | Nashville, Davidson County | $8.1M | 2005 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $7.4M | 2020 |
| Vanderbilt University | Nashville, Davidson County | $6.8M | 2004 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $6.4M | 2005 |
| Vanderbilt University | Nashville, Davidson County | $5.4M | 2009 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $5.3M | 2020 |
| Vanderbilt University | Nashville, Davidson County | $5M | 2002 |
| Vanderbilt University | Nashville, Davidson County | $4.5M | 1989 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.3M | 2019 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.1M | 2014 |
Source: USAspending.gov. Past awards show who this program funds; they don't guarantee future awards.
About the program (93.242)
Mental Health Research Grants
How applications are judged
The following consideration will be used in determining projects to be funded: (1) Technical merit of the proposed project as determined by peer review; (2) Availability of funds; and (3) Relevance to program priorities.
Matching requirements
This program has no statutory formula.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.
Examples of funded projects
Not Applicable.