National Institutes of Health · Department of Health and Human Services
Extracellular Vesicle Therapeutics for Regenerative Medicine (ExTReMe)
Key facts
- Deadline
- Forecast — the expected date (Feb 17, 2026) has passed; watch for the official notice
- Award size
- Not specified — see notice
- Cost share / match ?
- Not required
- Who can apply
- Tribal organization, Public college or university, Private college or university, Tribal government, Small business, State government, Other (see eligibility), School district, Larger business, County government, Nonprofit with 501(c)(3)
- Where
- Anywhere in the U.S., including Tennessee
Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Grant-ready checklist
How this fits you
- Available in Tennessee (nationwide program)
- No cost share required
- Tennessee recipients since 2023: 16
Tell us who you are to see whether you're eligible.
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Official notice: https://simpler.grants.gov/opportunity/2cefef55-df48-49f9-a95a-7719dae29481 · Printed from grantme.click/grants/e4b94ed1-31cc-4ae3-8cb1-2db6a1dcd72b
Read the official notice View on Grants.gov Sign in to save
About this grant
The National Center for Advancing Translational Science (NCATS) seeks to advance its mission by advancing research on extracellular vesicles (EVs) and their use as therapeutics in the field of regenerative medicine.
The main objective of this program, Extracellular Vesicle Therapeutics for Regenerative Medicine (ExTReMe), is to support the translation of EV-based therapeutics in regenerative medicine. EVs, like exosomes and microvesicles, are crucial mediators of intercellular communication, carrying diverse cargo like proteins, nucleic acids, and lipids. In regenerative medicine, EVs play a significant role by influencing cellular behaviors during tissue repair and regeneration. Due to their natural function in intercellular communication, EVs represent a novel, cell-free, therapeutic tool. EVs can be further engineered to deliver therapeutic agents or modulate signaling pathways involved in repair/regeneration.
Areas of interest for ExTReMe could include, but are not limited to:
• direct EV therapy (stem cell-isolated EVs produced under GLP conditions, and stored as off-the-shelf therapies);
• designer EVs (personalized to the individual patient’s needs).
Grant authorities that allow the National Center for Advancing Translational Science (NCATS) to forecast this opportunity are as follows: 42 U.S. Code § 287a - Cures Acceleration Network
Who in Tennessee has won this program
16 awards to Tennessee recipients in 2 counties since federal FY2023. Largest shown:
| Recipient | Where | Amount | FY |
|---|---|---|---|
| Vanderbilt University Medical Center | Nashville, Davidson County | $118.6M | 2017 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $31.4M | 2016 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $20.9M | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $19.9M | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $9.3M | 2017 |
| Vanderbilt University | Nashville, Davidson County | $7.6M | 2018 |
| Vanderbilt University | Nashville, Davidson County | $4.6M | 2020 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.6M | 2017 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $3M | 2018 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $1.8M | 2026 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $448K | 2021 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $386K | 2020 |
Source: USAspending.gov. Past awards show who this program funds; they don't guarantee future awards.
About the program (93.350)
National Center for Advancing Translational Sciences — NCATS
How applications are judged
The major elements in evaluating proposals include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives and (7) the availability of funds.
Matching requirements
This program has no statutory formula.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.
Examples of funded projects
Not Applicable.