National Institutes of Health · Department of Health and Human Services
Mechanistic Toxicology of METALS: Metal Exposure, Transport, Action, Localization, and Susceptibility (RP1 Clinical Trial Not Allowed)
Key facts
- Deadline
- Expected around Jan 5, 2027 (not yet confirmed)
- Award size
- $100K – $500K
- Total available
- $15M · about 20 awards
- Cost share / match ?
- Not required
- Who can apply
- City or town government, Larger business, State government, Other (see eligibility), Public college or university, Nonprofit with 501(c)(3), School district, Special district (utility, fire, etc.), Small business, Tribal organization, County government, Nonprofit without 501(c)(3), Private college or university, Tribal government
- Where
- Anywhere in the U.S., including Tennessee
Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Grant-ready checklist
How this fits you
- Available in Tennessee (nationwide program)
- No cost share required
- Tennessee recipients since 2023: 23
Tell us who you are to see whether you're eligible.
More from National Institutes of Health
- Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed) · Forecast — the expected date (Jul 15, 2025) has passed; watch for the official notice
- IGVF Data and Coordinating Center (U24 Clinical trials Not Allowed) · Forecast — the expected date (Jul 15, 2025) has passed; watch for the official notice
- Forecast to Renew the Notice of Funding Opportunity Announcement for the Multiple Chronic Disease Research Centers · Forecast — the expected date (Jul 25, 2025) has passed; watch for the official notice
- Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed) · Forecast — the expected date (Aug 22, 2025) has passed; watch for the official notice
- Forecast to Publish a Funding Opportunity Announcement for the Consortium on the Neurobiology of Adolescent Drinking in Adulthood (NADIA) Administrative Resource (Collaborative U24 - Clinical Trials not allowed) · Forecast — the expected date (Sep 30, 2025) has passed; watch for the official notice
- Forecast to Publish a Funding Opportunity Announcement for the Consortium on the Neurobiology of Adolescent Drinking in Adulthood (NADIA) Research Resource (Collaborative U24 - Clinical Trials not allowed) · Forecast — the expected date (Sep 30, 2025) has passed; watch for the official notice
Official notice: https://simpler.grants.gov/opportunity/2b9da5ac-c1a1-4a64-ac18-4c707c6925ed · Printed from grantme.click/grants/e4316a2a-d9a4-4846-bff9-7c78dff8271c
Read the official notice View on Grants.gov Add dates to my calendar Sign in to save
About this grant
The purpose of this funding opportunity is to support mechanistic research to understand how exposure to metals and metal-containing compounds alters biological processes relevant to human health. Of particular interest are studies that elucidate the absorption, distribution, transport, cellular trafficking, biological interactions, and mechanisms of action of metals, including mechanisms through which metals may alter immune homeostasis, cross the placental barrier, or gain access to and affect the central nervous system. Studies may employ experimental models, new approach methodologies, computational approaches, or leverage human biospecimens where these approaches are used to address defined mechanistic hypotheses.
Eligibility (from the notice)
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;
Who in Tennessee has won this program
23 awards to Tennessee recipients in 5 counties since federal FY2023. Largest shown:
| Recipient | Where | Amount | FY |
|---|---|---|---|
| Vanderbilt University | Nashville, Davidson County | $11.2M | 1975 |
| University Of Memphis | Memphis, Shelby County | $4.3M | 2010 |
| Vanderbilt University | Nashville, Davidson County | $3.9M | 2019 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $3.6M | 2024 |
| University Of Tennessee | Memphis, Shelby County | $2.8M | 2021 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $2.7M | 2020 |
| Vanderbilt University | Nashville, Davidson County | $2.6M | 1992 |
| University Of Tennessee | Memphis, Shelby County | $2.2M | 2022 |
| Vanderbilt University | Nashville, Davidson County | $1.9M | 2023 |
| Vanderbilt University | Nashville, Davidson County | $1.8M | 2017 |
| Foundation Instruments Inc | Collierville, Shelby County | $1.4M | 2019 |
| 490 Biotech Inc | Knoxville, Knox County | $985K | 2015 |
Source: USAspending.gov. Past awards show who this program funds; they don't guarantee future awards.
About the program (93.113)
Environmental Health — National Institute of Environmental Health Sciences
How applications are judged
The major elements in evaluating proposals include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to stated program objectives. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific and...
Matching requirements
This program has no statutory formula.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.
Examples of funded projects
Not Applicable.