Single source: Childhood Cancer Survivor Study (U24 Clinical Trial Not Allowed)

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to support the continuation of the Childhood Cancer Survivor Study (CCSS) that investigates the long-term morbidity and mortality associated with cancer treatments. The CCSS represents a multi-institutional, multidisciplinary collaborative research resource that currently has health-related data from 38,000 or more 5-year survivors of pediatric and adolescent cancer patients with a comparison sibling control cohort. This NOFO seeks to obtain additional age-related longitudinal information from the current cohort of survivors and to include pediatric cancer survivors receiving modern therapies. The goal of the CCSS is to serve as a data resource and a biorepository for researchers. The objectives are to use the resources to conduct cancer risk assessments, observational and intervention-based research studies associated with long-term outcomes across the life span of survivors with the intent of improving cancer treatments. This is a Forecast for a single source that will invite application(s) from eligible organization(s) to apply. Please see the Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.

This is a non-competitive funding opportunity intended to fund a single award. Through this single source, cooperative agreement Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits an application to fund a single award to the current recipient of the Childhood Cancer Survivor Study.

The major elements in evaluating applications include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the...