National Centers for Biomedical Imaging and Bioengineering (NCBIB) (P41 Clinical Trials Optional)

This Notice of Funding Opportunity (NOFO) encourages grant applications for National Centers for Biomedical Imaging and Bioengineering (NCBIB). NCBIB are national resource centers for conducting research and development on new technologies that are driven by the needs of basic, translational, and/or clinical researchers. NCBIB also make their technologies available to other investigators, train members of the research community in the use of the technologies and disseminate the technologies broadly.

Other Eligible Applicants · Indian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U. · S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Foreign Institutions · Non-domestic (non-U. · S.) Entities (Foreign Institutions) are not eligible to apply. · Non-domestic (non-U. · S.) components of U. · S. Organizations are not eligible to apply. · Foreign components, as defined in the NIH Grants Policy Statement, are allowed. · Number of Applications · Applicant organizations may submit more than one application, provided that each application is scientifically distinct. · NIH will not accept duplicate or highly overlapping applications under review at the same time per NIH Grants Policy Statement Section 2.3.7.4 Submission of Resubmission Application. This means that the NIH will not accept: A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application. · A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application. · An application that has substantial overlap with another application pending appeal of initial peer review (see NIH Grants Policy Statement 2.3.9.4 Similar, Essentially Identical, or Identical Applications). · Renewals: Applicants may submit a Renewal application. However, NIBIB NCBIB Awards will be restricted to a total of fifteen years.

The major elements in evaluating proposals include assessments of: (1) Significance: Does this study address an important problem? If the aims of the application are achieved, how will scientific knowledge be advanced? What will be the effect of these studies on the concepts or methods that drive this field? (2) Approach: Are the conceptual framework, design, methods, and analyses adequately developed, well-integrated, and appropriate to the aims of the project? Does the applicant acknowledge potential problem areas and consider alternative tactics? (3) Innovation: Does the project employ novel concepts, approaches or method? Are the aims original and innovative? Does the project challenge existing paradigms or develop new methodologies or technologies? (4) Investigator: Is the investigator appropriately trained and well suited to carry out this work? Is the work proposed appropriate to the experience level of the principal investigator and other researchers (if any)? (5) Environment: Does the scientific environment in which the work will be done contribute to the probability of success? Do the proposed experiments take advantage of unique features of the scientific environment or employ useful collaborative arrangements? Is there evidence of institutional support? (6) the appropriateness of the proposed budget and duration in relation to the proposed research; (7) the relevance and importance to announced program objectives; (8) the adequacy of plans to include both...