National Institutes of Health · Department of Health and Human Services
Centers for Structural Biology of HIV and Other Infectious Diseases (U54 Clinical Trial Not Allowed)
In short: National Institutes of Health gives grants of up to $3.5 million. Open to many kinds of groups. See who can apply.
Key facts
- Deadline
- Due May 28, 2027 · 231 days left
- Award size
- Up to $3.5M
- Total available
- $33M
- Match ?
- Not required · Work out your budget and match
- Who can apply
- Tribal government, City or town government, Public college or university, State government, Private college or university, Tribal organization, Special district (utility, fire, etc.), Nonprofit without 501(c)(3), County government, Larger business, Small business, Nonprofit with 501(c)(3), School district, and others named in the official notice
- Where
- Anywhere in the U.S., including Tennessee
Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Get-ready checklist
How this fits you
- Available in Roane County (nationwide program)
- No match required
- Past Tennessee awards on file: 296
Tell us who you are to see whether you're eligible.
About this grant
The purpose of this notice of funding opportunity (NOFO) is to support multidisciplinary consortia of structural biologists, microbiologists, and associated experts to solve complex biological structures related to the prevention, treatment, and cure of HIV and other infectious diseases. Centers are expected to facilitate new collaborations, leverage shared resources, offer services and resources to the research community, and train the next generation of scientists engaged in structural biology of infectious diseases.
Who can apply, from the official notice
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. · Foreign Organizations/International Collaborations · Non-domestic (non-U. · S.) Entities (Foreign Organization) are not eligible to apply. · Non-domestic (non-U. · S.) components of U. · S. Organizations are not eligible to apply. · Foreign components, as defined in the NIH Grants Policy Statement, are allowed. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards. · Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.
Official notice: https://simpler.grants.gov/opportunity/994a62bf-3ab5-4046-ad9f-e5abf6b89934 · Printed from grantme.click/grants/bed9d952-d571-4556-bdf2-0eac86b080ba
View on Grants.gov Add deadline to my calendar
Your schedule, working back from the deadline
- Oct9
Check that your SAM.gov registration is active (or start it now)
Grants.gov: allow up to 10 business days for SAM registration, weeks or months if information isn't verified. It must be renewed every year. Grants.gov - May7
Ask partners for letters of support or commitment
Suggested: partners need about three weeks to write and sign letters. - May21
Finish a complete draft for a final review
Suggested: leave about a week for someone else to read the draft. - May26
Submit
Grants.gov: submit at least 24–48 hours before the deadline: uploads fail, systems slow down, errors need fixing. Grants.gov blog - May28
Deadline
From the funder.
Save this grant to put these dates in My grants and your private calendar.
Writing the need statement? Roane County facts with citations.
See how others wrote it
The agency posted this example. Read them for structure and level of detail. Don't copy their words: funders treat copied text as plagiarism, and requirements change from year to year, so follow the current notice.
- NIH research, career, fellowship and small-business grants (R01, R03, R15, R21, R21/R33, R41-R44, K01, K08, K23, F31, G11, U01)
Funded applications with reviewer comments
46 full funded applications and 49 reviewer summary statements (PDF), plus sample forms and letters · Link checked Oct 7, 2026
Who in Tennessee has won this program
53 awards to Tennessee groups in 2 counties since 1996 · 0 in Roane County. Largest shown:
| Past winner | Where | Amount | Fiscal year |
|---|---|---|---|
| Vanderbilt University Medical Center | Nashville, Davidson County | $143.7M | 2016 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $63.8M spent that year | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $51.7M spent that year | 2025 |
| Meharry Medical College | Nashville, Davidson County | $45.7M | |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | $43.7M | 2019 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $43M | 2020 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $38.1M | 2024 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $33.3M | 2011 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $32.8M | 2007 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $32.8M | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $27.5M | 1997 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $22M | 2016 |
Source: USAspending.gov; Federal Audit Clearinghouse. Past awards show who this program funds. They don't guarantee future awards.
Tennessee groups that got this money through a state agency or another organization
This federal money also reaches local groups as pass-through grants. 243 pass-through grants on file · 0 in Roane County. Largest shown:
| Past winner | Where | Through | Amount | Fiscal year |
|---|---|---|---|---|
| Vanderbilt University Medical Center | Nashville, Davidson County | Yale Univ | $3.4M | 2023 |
| Meharry Medical College | Nashville, Davidson County | Vanderbilt University Medical Center | $2.8M | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Washington University, the | $2.8M | 2025 |
| Vanderbilt University | Nashville, Davidson County | Vanderbilt University Medical Center | $2.6M | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | University of Wisconsin System | $2.2M | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Washington University | $2.1M spent that year | 2025 |
| Vanderbilt University | Nashville, Davidson County | Vanderbilt University Medical Center | $2M | 2024 |
| Vanderbilt University Medical Center | Nashville, Davidson County | The Johns Hopkins University | $2M | 2026 |
| Vanderbilt University Medical Center | Nashville, Davidson County | University of Texas Medical Branch at Galveston | $2M spent that year | 2025 |
| Vanderbilt University | Nashville | Vumc | $1.9M spent that year | 2024 |
| Vanderbilt University | Nashville | Vanderbilt University Medical Center | $1.9M spent that year | 2025 |
| Vanderbilt University | Nashville | Vanderbilt University Medical Center | $1.8M spent that year | 2025 |
Source: USAspending.gov pass-through reports (the first recipient reports each one of $30,000 or more).
Similar grants open or opening soon
From other funders, about the same kind of work in Roane County.
- Rural Health Network Development Program · Health Resources and Services Administration · Opens Jan 14, 2027 · due about Mar 16, 2027 Estimate, not confirmed by the funder
- Comprehensive Suicide Prevention Program for States · Centers for Disease Control - NCIPC · Opens Feb 16, 2027 · due about Apr 17, 2027 Estimate, not confirmed by the funder
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About the federal program
Trans-NIH Research Support, also called “NIH-wide Research Support”
Program number 93.310 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Project grant, training
How applications are judged
Funding decisions are based on scientific merit (42 CFR 52h) and program relevance. Scientific merit review encompasses: the peer review criteria detailed in the specific funding announcement, as well as the significance, approach, and innovation of the proposed research; the competency of the principal investigator; the adequacy of the resources and environment; the proposed budget and requested period of support; and, where applicable, the adequacy of the measures for protecting against adverse effects upon humans, animals, or the environment.
Match
None required (federal program listing).
About the federal program
Allergy and Infectious Diseases Research, also called “National Institutes of Allergy and Infectious Diseases”
Program number 93.855 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Project grant
How applications are judged
The major elements in evaluating proposals include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific...
Match
None required (federal program listing).