National Institutes of Health · Department of Health and Human Services
Developing novel theory and methods for understanding the genetic architecture of complex human traits (R21 Clinical Trial Not Allowed)
Key facts
- Deadline
- Due Jan 7, 2027 · 92 days left
- Award size
- Not stated: see the official notice
- Match ?
- Not required · Work out your budget and match
- Who can apply
- Tribal organization, Larger business, Small business, State government, School district, Tribal government, Private college or university, Nonprofit without 501(c)(3), Nonprofit with 501(c)(3), Public college or university, City or town government, County government, Special district (utility, fire, etc.), and others named in the official notice
- Where
- Anywhere in the U.S., including Tennessee
Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Get-ready checklist
How this fits you
- Available in Blount County (nationwide program)
- No match required
- Past Tennessee awards on file: 84
Tell us who you are to see whether you're eligible.
Official notice: https://simpler.grants.gov/opportunity/7ab09c50-d4d8-4057-8347-d96c5cbc05cd · Printed from grantme.click/grants/bebcc011-0a92-4cbb-b598-a79eb0d2ad45
View on Grants.gov Add deadline to my calendar
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About this grant
The goal of this NOFO is to support R21 applications for novel theory and methods development that better delineate how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary across the natural and social sciences, account for interdependencies across scales of biological, social, and ecological organization, and make extensive use of theory, simulations, and validation using available large-scale datasets
Who can apply, from the official notice
Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Your schedule, working back from the deadline
- Oct7
Check that your SAM.gov registration is active (or start it now)
Grants.gov: allow up to 10 business days for SAM registration, weeks or months if information isn't verified. It must be renewed every year. Grants.gov - Dec17
Ask partners for letters of support or commitment
Suggested: partners need about three weeks to write and sign letters. - Dec31
Finish a complete draft for a final review
Suggested: leave about a week for someone else to read the draft. - Jan5
Submit
Grants.gov: submit at least 24–48 hours before the deadline: uploads fail, systems slow down, errors need fixing. Grants.gov blog - Jan7
Deadline
From the funder.
Save this grant to put these dates in My grants and your private calendar.
Writing the need statement? Blount County facts with citations.
Who in Tennessee has won this program
31 awards to Tennessee groups in 3 counties since 2005 · 0 in Blount County. Largest shown:
| Past winner | Where | Amount | Fiscal year |
|---|---|---|---|
| Vanderbilt University Medical Center | Nashville, Davidson County | $16.8M | 2020 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $13.3M spent that year | 2025 |
| Baptist Memorial Hospital-Tipton | Covington, Tipton County | $11.9M | 2014 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $8.1M | 2016 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $8M | 2018 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $7M | 2020 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | $6.8M | 2005 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | $5.2M | 2018 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.6M | 2022 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.5M | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.4M | 2024 |
| Vanderbilt University | Nashville, Davidson County | $4.3M | 2016 |
Source: USAspending.gov, Federal Audit Clearinghouse. Past awards show who this program funds. They don't guarantee future awards.
Tennessee groups that got this money through a state agency or another organization
This federal money also reaches local groups as pass-through grants. 53 pass-through grants on file · 0 in Blount County. Largest shown:
| Past winner | Where | Through | Amount | Fiscal year |
|---|---|---|---|---|
| Vanderbilt University | Nashville, Davidson County | Vanderbilt University Medical Center | $2.3M | 2023 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | Weill Medical College of Cornell University | $2.1M | 2026 |
| Vanderbilt University Medical Center | Nashville, Davidson County | University of Alabama at Birmingham | $1.5M | 2026 |
| Meharry Medical College | Nashville, Davidson County | Vanderbilt University Medical Center | $1.1M | 2023 |
| Meharry Medical College | Nashville, Davidson County | Vumc | $813K spent that year | 2023 |
| St. Jude Children's Research Hospital, Inc. | Memphis, Shelby County | Cornell University | $698K spent that year | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | University of North Carolina at Chapel Hill | $669K | 2023 |
| Meharry Medical College | Nashville, Davidson County | Vanderbilt University Medical Center | $545K | 2023 |
| Meharry Medical College | Nashville, Davidson County | Vanderbilt University Medical Center | $536K | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Broad Institute of Mit and Harvard | $455K spent that year | 2025 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | The Leland Stanford Junior University | $444K | 2024 |
| St. Jude Children's Research Hospital, Inc. | Memphis, Shelby County | Stanford University | $432K spent that year | 2025 |
Source: USAspending.gov pass-through reports (the first recipient reports each one of $30,000 or more).
About the federal program
Human Genome Research, also called “National Human Genome Research Institute”
Program number 93.172 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Project grant
How applications are judged
In each year's official notice: read this year's.
Match
None required (federal program listing).
Examples of funded projects
Fiscal year 2025: Examples of research supported by NHGRI in FY 2025 include characterization of genes, sequencing, databases, and projects on the following list: https://reporter.nih.gov/search/KP6XtPborUWv7kYNeFlJSA/projects?shared=true
Fiscal year 2026: Current projects supported by NHGRI include basic genomic science; functional and clinical variation; genomic medicine; technology development; computational genomics and data science; training programs; conferences; databases; determining the ethical, legal, and social implications (ELSI) of biomedical and behavioral research; as well as projects on the following list:
https://reporter.nih.gov/search/PbojAWqEZ0aySDrGRZXHTg/projects?shared=true
About the federal program
Cancer Control, also called “Cancer Control Grants”
Program number 93.399 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Project grant
How applications are judged
The major elements in evaluating proposals include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives.
Match
None required (federal program listing).