National Institutes of Health · Department of Health and Human Services
Developing novel theory and methods for understanding the genetic architecture of complex human traits (R21 Clinical Trial Not Allowed)
Key facts
- Deadline
- Due Jan 7, 2027 · 93 days left
- Award size
- Not specified — see notice
- Cost share / match
- Not required
- Who can apply
- Tribal organization, Larger business, Small business, Other (see eligibility), State government, School district, Tribal government, Private college or university, Nonprofit without 501(c)(3), Nonprofit with 501(c)(3), Public college or university, City or town government, County government, Special district (utility, fire, etc.)
- Where
- Anywhere in the U.S., including Tennessee
Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Grant-ready checklist
How this fits you
- Available in Tennessee (nationwide program)
- No cost share required
- Tennessee recipients since 2023: 25
Tell us who you are to see whether you're eligible.
Read the official notice View on Grants.gov Add deadline to my calendar
About this grant
The goal of this NOFO is to support R21 applications for novel theory and methods development that better delineate how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary across the natural and social sciences, account for interdependencies across scales of biological, social, and ecological organization, and make extensive use of theory, simulations, and validation using available large-scale datasets
Eligibility (from the notice)
Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Who in Tennessee has won this program
25 awards to Tennessee recipients in 3 counties since federal FY2023. Largest shown:
| Recipient | Where | Amount | FY |
|---|---|---|---|
| Vanderbilt University Medical Center | Nashville, Davidson County | $16.8M | 2020 |
| Baptist Memorial Hospital-Tipton | Covington, Tipton County | $11.9M | 2014 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $8.1M | 2016 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $8M | 2018 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $7M | 2020 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | $6.8M | 2005 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | $5.2M | 2018 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.6M | 2022 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.5M | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.4M | 2024 |
| Vanderbilt University | Nashville, Davidson County | $4.3M | 2016 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.3M | 2022 |
Source: USAspending.gov. Past awards show who this program funds; they don't guarantee future awards.
About the program (93.172)
Human Genome Research — National Human Genome Research Institute
How applications are judged
Criteria for selecting proposals is described at the NOFO level.
Matching requirements
This program has no statutory formula.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.
Examples of funded projects
Fiscal Year2025: Examples of research supported by NHGRI in FY 2025 include characterization of genes, sequencing, databases, and projects on the following list: https://reporter.nih.gov/search/KP6XtPborUWv7kYNeFlJSA/projects?shared=trueFiscal Year2026: Current projects supported by NHGRI include basic genomic science; functional and clinical variation; genomic medicine; technology development; computational genomics and data science; training programs; conferences; databases; determining the ethical, legal, and social implications (ELSI) of biomedical and behavioral research; as well as projects on the following list:
https://reporter.nih.gov/search/PbojAWqEZ0aySDrGRZXHTg/projects?shared=true
About the program (93.399)
Cancer Control — Cancer Control Grants
How applications are judged
The major elements in evaluating proposals include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives.
Matching requirements
This program has no statutory formula.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.
Examples of funded projects
Not Applicable.