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U.S. National Science Foundation

Mathematical Foundations of Artificial Intelligence (MFAI)

Closed

In short: U.S. National Science Foundation gives grants of $500,000 to $1.5 million.

Key facts

Deadline
Closed Oct 9, 2026
Award size
$500K – $1.5M
Total available
$8.5M
Match ?
Not required · Work out your budget and match
Who can apply
Set by the official notice: see Who can apply below
Where
Anywhere in the U.S., including Tennessee

What changed

  • Status changed from open to closed (seen Oct 10, 2026)

Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Get-ready checklist

How this fits you

  • Available in Unicoi County (nationwide program)
  • No match required
  • Past Tennessee awards on file: 261

Tell us who you are to see whether you're eligible.

About this grant

Machine Learning and Artificial Intelligence (AI) are enabling extraordinary scientific breakthroughs in fields ranging from protein folding, natural language processing, drug synthesis, and recommender systems to the discovery of novel engineering materials and products. These achievements lie at the confluence of mathematics, statistics, engineering and computer science, yet a clear explanation of the remarkable power and also the limitations of such AI systems has eluded scientists from all disciplines. Critical foundational gaps remain that, if not properly addressed, will soon limit advances in machine learning, curbing progress in artificial intelligence. It appears increasingly unlikely that these critical gaps can be surmounted with increased computational power and experimentation alone. Deeper mathematical understanding is essential to ensuring that AI can be harnessed to meet the future needs of society and enable broad scientific discovery, while forestalling the unintended consequences of a disruptive technology. The National Science Foundation Directorates for Mathematical and Physical Sciences (MPS), Computer and Information Science and Engineering (CISE), Engineering (ENG), and Social, Behavioral and Economic Sciences (SBE) will jointly sponsor research collaborations consisting of mathematicians, statisticians, computer scientists, engineers, and social and behavioral scientists focused on the mathematical and theoretical foundations of AI. Research activities should focus on the most challenging mathematical and theoretical questions aimed at understanding the capabilities, limitations, and emerging properties of AI methods as well as the development of novel, and mathematically grounded, design and analysis principles for the current and next generation of AI approaches. Specific research goals include: establishing a fundamental mathematical understanding of the factors determining the capabilities and limitations of current and emerging generations of AI systems, including, but not limited to, foundation models, generative models, deep learning, statistical learning, federated learning, and other evolving paradigms; the development of mathematically grounded design and analysis principles for the current and next generations of AI systems; rigorous approaches for characterizing and validating machine learning algorithms and their...

Who can apply, from the official notice

*Who May Submit Proposals: Proposals may only be submitted by the following: -Non-profit, non-academic organizations: Independent museums, observatories, research laboratories, professional societies and similar organizations located in the U.S. that are directly associated with educational or research activities. -Institutions of Higher Education (IHEs) - Two- and four-year IHEs (including community colleges) accredited in, and having a campus located in the US, acting on behalf of their faculty members. *Who May Serve as PI: As of the date the proposal is submitted, any PI, co-PI, or senior/key personnel must hold either: a tenured or tenure-track position, or a primary, full-time, paid appointment in a research or teaching position at a US-based campus of an organization eligible to submit to this solicitation (see above), with exceptions granted for family or medical leave, as determined by the submitting organization. Individuals with primary appointments at for-profit non-academic organizations or at overseas branch campuses of U.S. institutions of higher education are not eligible.

View on Grants.gov

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Writing the need statement? Unicoi County facts with citations.

Who in Tennessee has won this program

101 awards to Tennessee groups in 5 counties since 2017 · 0 in Unicoi County. Largest shown:

Past Tennessee winners
Past winnerWhereAmountFiscal year
State of TennesseeNashville$12.2M spent that year2025
University of TennesseeKnoxville, Knox County$11.7M2023
University of TennesseeKnoxville, Knox County$9M2026
State of TennesseeNashville$7.7M spent that year2025
State of TennesseeNashville$6.7M spent that year2025
Vanderbilt UniversityNashville$6.1M spent that year2025
Vanderbilt UniversityNashville$4.5M spent that year2025
Vanderbilt UniversityNashville, Davidson County$4M2025
Vanderbilt UniversityNashville$3.5M spent that year2025
Vanderbilt UniversityNashville, Davidson County$3.2M2022
Vanderbilt UniversityNashville, Davidson County$3M2024
University of TennesseeKnoxville, Knox County$2.8M2022

Source: Federal Audit Clearinghouse; USAspending.gov. Past awards show who this program funds. They don't guarantee future awards.

Tennessee groups that got this money through a state agency or another organization

This federal money also reaches local groups as pass-through grants. 160 pass-through grants on file · 0 in Unicoi County. Largest shown:

Tennessee pass-through grant winners
Past winnerWhereThroughAmountFiscal year
Fisk UniversityNashville, Davidson CountyVanderbilt University$956K2024
State of TennesseeNashvilleThe Ohio State University$849K spent that year2025
Vanderbilt UniversityNashville, Davidson CountyUniversity of California Santa Cruz$792K2023
University of TennesseeKnoxville, Knox CountyArizona State University$638K2026
University of TennesseeKnoxville, Knox CountyUniversity of Texas at San Antonio, the$490K2024
University of TennesseeKnoxville, Knox CountyUniversity of Southern California$460K2026
State of TennesseeNashvilleUniversity of Illinois$453K spent that year2023
Vanderbilt UniversityNashville, Davidson CountyUniversity of Florida$396K2026
Vanderbilt UniversityNashville, Davidson CountyTexas a & M University$388K2023
University of TennesseeKnoxville, Knox CountyThe University of Texas at San Antonio$386K2024
University of TennesseeKnoxville, Knox CountyBoard of Regents of the Nevada System of Higher Ed$370K2026
St. Jude Children's Research Hospital, Inc.Memphis, Shelby CountyUniversity of California-Berkeley (UCB)$311K spent that year2025

Source: USAspending.gov pass-through reports (the first recipient reports each one of $30,000 or more).

More from U.S. National Science Foundation

About the federal program

Engineering, also called “(ENG)”
Program number 47.041 (the federal Assistance Listing number) · National Science Foundation · Project grant

Match

None required (federal program listing).

This program on SAM.gov

About the federal program

Mathematical and Physical Sciences, also called “(MPS)”
Program number 47.049 (the federal Assistance Listing number) · National Science Foundation · Project grant

Match

None required (federal program listing).

This program on SAM.gov

About the federal program

Computer and Information Science and Engineering, also called “(CISE)”
Program number 47.070 (the federal Assistance Listing number) · National Science Foundation · Project grant

Match

None required (federal program listing).

This program on SAM.gov

About the federal program

Social, Behavioral, and Economic Sciences, also called “(SBE)”
Program number 47.075 (the federal Assistance Listing number) · National Science Foundation · Project grant

Match

None required (federal program listing).

This program on SAM.gov

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