National Institutes of Health · Department of Health and Human Services
Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) Infrastructure – Clinical Enrollment Hubs
Key facts
- Deadline
- Opens Jan 4, 2027 · due about Mar 4, 2027 (estimate)
- Award size
- Not specified — see notice
- Cost share / match ?
- Not required · Work out your budget and match
- Who can apply
- Private college or university, Tribal organization, Other (see eligibility), County government, State government, Public college or university, Special district (utility, fire, etc.), City or town government, School district, Tribal government, Larger business, Nonprofit without 501(c)(3), Nonprofit with 501(c)(3), Small business
- Where
- Anywhere in the U.S., including Tennessee
Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Grant-ready checklist
How this fits you
- Available in Tennessee (nationwide program)
- No cost share required
- Past Tennessee awards on file: 41
Tell us who you are to see whether you're eligible.
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Official notice: https://simpler.grants.gov/opportunity/25f595e2-1671-4aae-a760-e3487a3d282c · Printed from grantme.click/grants/9d3b3ae4-58cc-4ad7-98db-e1663450b1b2
Read the official notice View on Grants.gov Add dates to my calendar Sign in to save
About this grant
The National Institute of Neurological Disorders and Stroke (NINDS), in conjunction with The National Heart, Lung and Blood Institute (NHLBI), at the National Institutes of Health (NIH) seek to continue to support the Infrastructure for the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN). The program will encourage applications for network clinical enrollment hubs to support the NIH SIREN clinical trial network. The SIREN Network performs clinical trials that impact the care of individuals with a non-stroke neurological and cardiovascular emergency in the pre-hospital or emergency department setting. The goal of SIREN is to improve the outcomes by identifying effective treatments given in the earliest stages of care.
Applications are not being solicited at this time. This notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive applications for centers.
Eligibility (from the notice)
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
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Who in Tennessee has won this program
19 awards to Tennessee recipients in 2 counties since 1993. Largest shown:
| Recipient | Where | Amount | FY |
|---|---|---|---|
| Vanderbilt University Medical Center | Nashville, Davidson County | $7.6M | 2012 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | $7.1M | 2017 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $5.3M | 2016 |
| University Of Tennessee | Memphis, Shelby County | $5.3M | 2002 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | $5.2M | 1998 |
| Vanderbilt University | Nashville, Davidson County | $4.7M | 2001 |
| Vanderbilt University | Nashville, Davidson County | $4.6M | 2016 |
| Vanderbilt University | Nashville, Davidson County | $4.1M | 1993 |
| Vanderbilt University | Nashville, Davidson County | $3.9M | 2022 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | $3.8M | 2021 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | $3.7M | 2017 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | $3.7M | 2011 |
Source: USAspending.gov. Past awards show who this program funds; they don't guarantee future awards.
Tennessee groups that got this money through a state agency or another grantee
This federal money also reaches local groups as subawards. 22 subawards on file. Largest shown:
| Recipient | Where | Through | Amount | FY |
|---|---|---|---|---|
| Vanderbilt University | Nashville, Davidson County | Yale Univ | $1.6M | 2023 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | University of Miami | $654K | 2023 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | University of Miami | $588K | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | The University of Iowa | $538K | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | University of Utah | $441K | 2025 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | Mayo Clinic Jacksonville (a Nonprofit Corporation) | $431K | 2024 |
| Vanderbilt University Medical Center | Nashville, Davidson County | New York University | $388K | 2024 |
| Vanderbilt University Medical Center | Nashville, Davidson County | New York University | $388K | 2024 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Dignity Health | $368K | 2024 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | The Children's Hospital of Philadelphia | $350K | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | The University of Iowa | $347K | 2026 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Mayo Clinic | $346K | 2024 |
Source: USAspending.gov subaward reports (prime recipients report subawards of $30,000 or more).
About the program (93.853)
Extramural Research Programs in the Neurosciences and Neurological Disorders
How applications are judged
The major elements in evaluating proposals include assessments of: (1) the scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) the soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) the degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific...
Matching requirements
This program has no statutory formula.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.
Examples of funded projects
Not Applicable.