National Institutes of Health · Department of Health and Human Services
Somatic Mosaicism across Human Tissues (SMaHT) Program: Tissue Procurement Center (R24 Clinical Trial Not Allowed)
Key facts
- Deadline
- Expected around Jul 1, 2027 (not yet confirmed)
- Award size
- Not specified — see notice
- Cost share / match ?
- Not required
- Who can apply
- Private college or university, Tribal organization, County government, Tribal government, Other (see eligibility), City or town government, Larger business, Public college or university, Special district (utility, fire, etc.), School district, State government, Nonprofit with 501(c)(3), Small business, Nonprofit without 501(c)(3)
- Where
- Anywhere in the U.S., including Tennessee
Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Grant-ready checklist
How this fits you
- Available in Tennessee (nationwide program)
- No cost share required
- Tennessee recipients since 2023: 23
Tell us who you are to see whether you're eligible.
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Official notice: https://simpler.grants.gov/opportunity/16ef7348-6afd-4740-ad2a-45bd12c45e7f · Printed from grantme.click/grants/974b3084-e1b7-42fd-8eca-b6b693f952b9
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About this grant
The purpose of the Somatic Mosaicism across Human Tissues (SMaHT) Network is to advance the discovery of biological processes and disease mechanisms mediated by somatic mutations in human tissues.
Since 2023, the program has generated multi-omic somatic mutation datasets from a standardized set of human tissues spanning all three germ layers. Building on the Stage 1 foundation, the NIH intends to issue a Notice of Funding Opportunity (NOFO) seeking support for the SMaHT Tissue Procurement Center (TPC) initiative.
The TPC will enable functional analyses of these healthy and clinically relevant tissue samples, providing critical resources to support characterization of somatic mosaicism and its role in human biology and disease. The Tissue Procurement Center will support the Network by collecting, processing, storing, and rapidly distributing high-quality, well-characterized human tissue specimens. Building on the 150 healthy donors enrolled during Stage 1, the TPC will procure tissues from at least 50 additional healthy donors, bringing the total to 200. The TPC will also collect up to 10 special tissue cohorts. The special tissue cohorts may include: tissues that can be grown in culture, tissues that are of high interest for somatic mosaicism studies, clinically relevant samples, organs that require special handling procedures, and other relevant samples. Awardee will collaborate with other SMaHT Stage 2 initiatives to ensure that the samples are sufficient and useful for running production level assays within the program.
Eligibility (from the notice)
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
Who in Tennessee has won this program
23 awards to Tennessee recipients in 2 counties since federal FY2023. Largest shown:
| Recipient | Where | Amount | FY |
|---|---|---|---|
| Vanderbilt University Medical Center | Nashville, Davidson County | $143.7M | 2016 |
| Meharry Medical College | Nashville, Davidson County | $45.7M | |
| Vanderbilt University Medical Center | Nashville, Davidson County | $32.8M | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $27.5M | 1997 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $22M | 2016 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $19.6M | 2011 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $12.6M | 2016 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $9.3M | 2021 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $8.5M | 2022 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $8M | 2025 |
| University Of Memphis | Memphis, Shelby County | $7.7M | 2020 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $7.4M | 2002 |
Source: USAspending.gov. Past awards show who this program funds; they don't guarantee future awards.
About the program (93.310)
Trans-NIH Research Support — NIH-wide Research Support
How applications are judged
Funding decisions are based on scientific merit (42 CFR 52h) and program relevance. Scientific merit review encompasses: the peer review criteria detailed in the specific funding announcement, as well as the significance, approach, and innovation of the proposed research; the competency of the principal investigator; the adequacy of the resources and environment; the proposed budget and requested period of support; and, where applicable, the adequacy of the measures for protecting against adverse effects upon humans, animals, or the environment.
Matching requirements
This program has no statutory formula.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.
Examples of funded projects
Not Applicable.