National Institutes of Health · Department of Health and Human Services
Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)
In short: A grant from National Institutes of Health. Open to many kinds of groups. See who can apply.
Key facts
- Deadline
- Due Mar 5, 2027 · 147 days left
- Award size
- Not stated: see the official notice
- Match ?
- Not required · Work out your budget and match
- Who can apply
- State government, Public college or university, Tribal organization, Nonprofit with 501(c)(3), Private college or university, County government, Nonprofit without 501(c)(3), Tribal government, Small business, City or town government, School district, Special district (utility, fire, etc.), Larger business, and others named in the official notice
- Where
- Anywhere in the U.S., including Tennessee
Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Get-ready checklist
How this fits you
- Available in Blount County (nationwide program)
- No match required
- Past Tennessee awards on file: 374
Tell us who you are to see whether you're eligible.
About this grant
The purpose of this Notice of Funding Opportunity (NOFO) is to support investigators who have the interest and capability to join efforts for the discovery of in vivo chemical probes for novel brain targets. It is expected that applicants will have, in hand, the starting compounds (validated hits) for chemical optimization and bioassays for testing new analog compounds.Through this NOFO, NIH wishes to stimulate research in:Discovery and development of novel, small molecules for their potential use in understanding biological processes relevant to the missions of National Institute of Mental Health (NIMH), National Institute on Drug Abuse (NIDA), National Eye Institute (NEI), and/or National Institute on Aging (NIA) andDiscovery and/or validation of novel, biological targets that will inform studies of brain disease mechanisms.Emphasis will be placed on projects that provide new insight into important disease-related biological targets and biological processes.
Who can apply, from the official notice
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. · Foreign Organizations/International Collaborations · Non-domestic (non-U. · S.) Entities (Foreign Organizations) are eligible to apply. · Non-domestic (non-U. · S.) components of U. · S. Organizations are eligible to apply. · Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Official notice: https://simpler.grants.gov/opportunity/a968f5d6-6f8f-49af-895d-b25227674717 · Printed from grantme.click/grants/81644d42-d90e-4550-ab87-ce1b556d0c57
View on Grants.gov Add deadline to my calendar
Your schedule, working back from the deadline
- Oct9
Check that your SAM.gov registration is active (or start it now)
Grants.gov: allow up to 10 business days for SAM registration, weeks or months if information isn't verified. It must be renewed every year. Grants.gov - Feb12
Ask partners for letters of support or commitment
Suggested: partners need about three weeks to write and sign letters. - Feb26
Finish a complete draft for a final review
Suggested: leave about a week for someone else to read the draft. - Mar3
Submit
Grants.gov: submit at least 24–48 hours before the deadline: uploads fail, systems slow down, errors need fixing. Grants.gov blog - Mar5
Deadline
From the funder.
Save this grant to put these dates in My grants and your private calendar.
Writing the need statement? Blount County facts with citations.
Who in Tennessee has won this program
102 awards to Tennessee groups in 4 counties since 1978 · 0 in Blount County. Largest shown:
| Past winner | Where | Amount | Fiscal year |
|---|---|---|---|
| Vanderbilt University Medical Center | Nashville, Davidson County | $39.5M spent that year | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $37.5M | 2021 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $24.1M | 2011 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $18.6M | 2024 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $18.3M | 2019 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | $14.9M | 2015 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $14.9M spent that year | 2025 |
| Vanderbilt University | Nashville | $14.8M spent that year | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $14M | 1997 |
| Vanderbilt University | Nashville, Davidson County | $12.7M | 2021 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $10M | 2025 |
| Vanderbilt University | Nashville, Davidson County | $9.4M | 1997 |
Source: Federal Audit Clearinghouse; USAspending.gov. Past awards show who this program funds. They don't guarantee future awards.
Tennessee groups that got this money through a state agency or another organization
This federal money also reaches local groups as pass-through grants. In Tennessee, Tennessee Department of Mental Health and Substance Abuse Services and Tennessee Department of Education pass it on: watch those agencies for applications, not the federal agency. 272 pass-through grants on file · 0 in Blount County. Largest shown:
| Past winner | Where | Through | Amount | Fiscal year |
|---|---|---|---|---|
| Vanderbilt University Medical Center | Nashville, Davidson County | University of Vermont & State Agricultural College | $4.4M | 2023 |
| University of Tennessee | Memphis, Shelby County | Virginia Polytechnic Institute & State University | $1.8M | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | The Trustees of Princeton University | $1.6M | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Regents of the University of Michigan | $1.4M | 2024 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | The University of Texas Southwestern Medical Center | $1.4M | 2026 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Vanderbilt University | $1.3M spent that year | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | University of Texas Health Science Center at Houston | $1.2M | 2026 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Vanderbilt University | $1.2M spent that year | 2025 |
| Vanderbilt University | Nashville, Davidson County | The Pennsylvania State University | $1.1M | 2026 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Mayo Clinic | $1M | 2026 |
| Vanderbilt University Medical Center | Nashville, Davidson County | University of Texas Health Science Center at Houston | $993K | 2024 |
| Vanderbilt University | Nashville, Davidson County | Vanderbilt University Medical Center | $979K | 2023 |
Source: USAspending.gov pass-through reports (the first recipient reports each one of $30,000 or more).
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About the federal program
Mental Health Research Grants
Program number 93.242 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Cooperative agreement (a grant with close agency involvement), project grant, training
How applications are judged
The following consideration will be used in determining projects to be funded: (1) Technical merit of the proposed project as determined by peer review; (2) Availability of funds; and (3) Relevance to program priorities.
Match
None required (federal program listing).
About the federal program
Drug Use and Addiction Research Programs
Program number 93.279 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Project grant, training
How applications are judged
The following considerations will be used in determining projects to be funded: (1) Scientific and technical merit; (2) the feasibility of the research; (3) potential contribution to the national drug abuse problem; and (4) relevance to NIDA priorities. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific and technical merit of the proposed approach for achieving the Phase II objectives; (3) the qualifications of the proposed principal investigator, supporting staff, and consultants; (4) the technology.
Match
None required (federal program listing).
About the federal program
Aging Research, also called “(Aging)”
Program number 93.866 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Project grant
How applications are judged
The major elements in evaluating proposals include assessments of: the scientific merit and general significance of the proposed study and its objectives; the technical adequacy of the experimental design and approach; the competency of the proposed investigator or group to successfully pursue the project; the adequacy of the available and proposed facilities and resources; the necessity of the budget components requested in relation to the proposed project; and the relevance and importance to announced program objectives. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific and technical merit of the proposed...
Match
None required (federal program listing).
About the federal program
Vision Research, also called “NEI”
Program number 93.867 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Project grant
How applications are judged
The following consideration will be used in determining projects to be funded: (1) Technical merit of the proposed project; (2) Availability of funds; and (3) Relevance to program priorities.
Match
None required (federal program listing).