National Institutes of Health · Department of Health and Human Services
Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)
In short: National Institutes of Health gives grants of up to $3 million. Open to many kinds of groups. See who can apply.
Key facts
- Deadline
- Accepts applications through Aug 21, 2028. Rounds may close sooner: check the notice
- Award size
- Up to $3M
- Match ?
- Not required · Work out your budget and match
- Who can apply
- City or town government, Nonprofit with 501(c)(3), State government, Tribal government, County government, Larger business, Public college or university, Special district (utility, fire, etc.), School district, Nonprofit without 501(c)(3), Tribal organization, Small business, Private college or university, and others named in the official notice
- Where
- Anywhere in the U.S., including Tennessee
Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Get-ready checklist
How this fits you
- Available in Gibson County (nationwide program)
- No match required
- Past Tennessee awards on file: 65
Tell us who you are to see whether you're eligible.
About this grant
The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including medications and medical devices to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption. This NOFO will utilize the UG3/UH3 activity code.
Who can apply, from the official notice
Other Eligible Applicants include the following:
Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession.
Official notice: https://simpler.grants.gov/opportunity/e18ff1b5-c4e9-4868-8e28-f34a9b023d19 · Printed from grantme.click/grants/80ec42b9-f06a-42da-9662-fe031e1fae07
View on Grants.gov Add deadline to my calendar
Your schedule, working back from the deadline
- Oct9
Check that your SAM.gov registration is active (or start it now)
Grants.gov: allow up to 10 business days for SAM registration, weeks or months if information isn't verified. It must be renewed every year. Grants.gov - Jul31
Ask partners for letters of support or commitment
Suggested: partners need about three weeks to write and sign letters. - Aug14
Finish a complete draft for a final review
Suggested: leave about a week for someone else to read the draft. - Aug19
Submit
Grants.gov: submit at least 24–48 hours before the deadline: uploads fail, systems slow down, errors need fixing. Grants.gov blog - Aug21
Deadline
From the funder.
Save this grant to put these dates in My grants and your private calendar.
Writing the need statement? Gibson County facts with citations.
Who in Tennessee has won this program
23 awards to Tennessee groups in 4 counties since 2016 · 0 in Gibson County. Largest shown:
| Past winner | Where | Amount | Fiscal year |
|---|---|---|---|
| Vanderbilt University | Nashville | $4.9M spent that year | 2025 |
| State of Tennessee | Nashville | $4.6M spent that year | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.5M | 2016 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.4M | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.2M spent that year | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4M | 2022 |
| University of Tennessee | Memphis, Shelby County | $3.9M | 2017 |
| Meharry Medical College | Nashville, Davidson County | $3.7M | 2022 |
| University of Tennessee | Knoxville, Knox County | $3.5M | 2019 |
| University of Tennessee | Memphis, Shelby County | $3.4M | 2021 |
| University of Tennessee | Memphis, Shelby County | $3.1M | 2019 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | $3.1M | 2022 |
Source: Federal Audit Clearinghouse; USAspending.gov. Past awards show who this program funds. They don't guarantee future awards.
Tennessee groups that got this money through a state agency or another organization
This federal money also reaches local groups as pass-through grants. 42 pass-through grants on file · 0 in Gibson County. Largest shown:
| Past winner | Where | Through | Amount | Fiscal year |
|---|---|---|---|---|
| Vanderbilt University Medical Center | Nashville, Davidson County | Vanderbilt University | $1.2M spent that year | 2025 |
| State of Tennessee | Nashville | University of California, San Diego | $397K spent that year | 2023 |
| Ut-Battelle LLC | Oak Ridge, Anderson County | Research Triangle Institute | $368K | 2023 |
| Vanderbilt University | Nashville | Denovx, LLC | $366K spent that year | 2024 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | University of Kentucky Research Foundation, the | $361K | 2023 |
| Ut-Battelle LLC | Oak Ridge, Anderson County | Research Triangle Institute | $345K | 2023 |
| Ut-Battelle LLC | Oak Ridge, Anderson County | Research Triangle Institute | $345K | 2024 |
| Ut-Battelle LLC | Oak Ridge, Anderson County | Research Triangle Institute | $344K | 2024 |
| Ut-Battelle LLC | Oak Ridge, Anderson County | Research Triangle Institute | $319K | 2024 |
| Ut-Battelle LLC | Oak Ridge | Research Triangle Institute | $319K | 2026 |
| Ut-Battelle LLC | Oak Ridge | Research Triangle Institute | $319K | 2026 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Meharry Medical College | $291K spent that year | 2025 |
Source: USAspending.gov pass-through reports (the first recipient reports each one of $30,000 or more).
Similar grants open or opening soon
From other funders, about the same kind of work in Gibson County.
- Fiscal Year 2027 Regional Nutrition Hubs · Health Resources and Services Administration · Opens Oct 15, 2026 · due about Dec 15, 2026 Estimate, not confirmed by the funder
- New Investigator Grants to Conduct Research to Prevent Interpersonal Violence and Suicide Among Children and Adolescents (K01) · Centers for Disease Control and Prevention - ERA · Due about Dec 1, 2026 Estimate, not confirmed by the funder
- Cooperative Research Agreements Related to the World Trade Center Health Program (U01) · Centers for Disease Control and Prevention - ERA · Due Dec 8, 2026 · 60 days left
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- Forecast to Publish a Funding Opportunity Announcement for the Consortium on the Neurobiology of Adolescent Drinking in Adulthood (NADIA) Research Resource (Collaborative U24 - Clinical Trials not allowed) · The funder's estimated date (Sep 30, 2025) has passed. Check the official notice Estimate, not confirmed by the funder
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About the federal program
Drug Use and Addiction Research Programs
Program number 93.279 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Project grant, training
How applications are judged
The following considerations will be used in determining projects to be funded: (1) Scientific and technical merit; (2) the feasibility of the research; (3) potential contribution to the national drug abuse problem; and (4) relevance to NIDA priorities. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific and technical merit of the proposed approach for achieving the Phase II objectives; (3) the qualifications of the proposed principal investigator, supporting staff, and consultants; (4) the technology.
Match
None required (federal program listing).