National Institutes of Health · Department of Health and Human Services
Impact of Immunotherapies on CNS Outcomes in People with HIV: Potential Benefits, Challenges and Risks
Key facts
- Deadline
- Expected around Oct 22, 2026 (not yet confirmed)
- Award size
- Not specified — see notice
- Total available
- $2M · about 4 awards
- Cost share / match
- Not required
- Who can apply
- Nonprofit without 501(c)(3), Other (see eligibility), School district, Tribal government, Special district (utility, fire, etc.), Private college or university, Larger business, State government, Tribal organization, City or town government, Public college or university, County government, Small business, Nonprofit with 501(c)(3)
- Where
- Anywhere in the U.S., including Tennessee
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How this fits you
- Available in Tennessee (nationwide program)
- No cost share required
- Tennessee recipients since 2023: 22
Tell us who you are to see whether you're eligible.
Read the official notice View on Grants.gov Add dates to my calendar
About this grant
The National Institute of Mental Health (NIMH) intends to publish a notice of funding opportunity (NOFO) to solicit biphasic research applications to evaluate the impact of HIV immunotherapies on central nervous system (CNS) outcomes in people with HIV and to identify mechanisms, benefits, and risks associated with their use in the CNS compartment. The primary goal is to generate evidence that informs whether HIV immunotherapies can safely and effectively target CNS HIV persistence while minimizing neurotoxicity and neuroinflammation. By addressing CNS-specific barriers such as blood brain barrier penetration, compartmentalized viral dynamics, and immune-mediated effects, this NOFO will support the development of strategies that contribute to sustained virologic remission across anatomical compartments and improve long-term neurologic and cognitive outcomes in people with HIV. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise and insights into the impact of HIV immunotherapies on the CNS and viral reservoirs are strongly encouraged to apply to this new NOFO. This NOFO will utilize the R21/R33 activity code.
Eligibility (from the notice)
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;
Who in Tennessee has won this program
22 awards to Tennessee recipients in 2 counties since federal FY2023. Largest shown:
| Recipient | Where | Amount | FY |
|---|---|---|---|
| Vanderbilt University | Nashville, Davidson County | $8.7M | 2001 |
| Vanderbilt University | Nashville, Davidson County | $8.7M | 2006 |
| Vanderbilt University | Nashville, Davidson County | $8.1M | 2005 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $7.4M | 2020 |
| Vanderbilt University | Nashville, Davidson County | $6.8M | 2004 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $6.4M | 2005 |
| Vanderbilt University | Nashville, Davidson County | $5.4M | 2009 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $5.3M | 2020 |
| Vanderbilt University | Nashville, Davidson County | $5M | 2002 |
| Vanderbilt University | Nashville, Davidson County | $4.5M | 1989 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.3M | 2019 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.1M | 2014 |
Source: USAspending.gov. Past awards show who this program funds; they don't guarantee future awards.
About the program (93.242)
Mental Health Research Grants
How applications are judged
The following consideration will be used in determining projects to be funded: (1) Technical merit of the proposed project as determined by peer review; (2) Availability of funds; and (3) Relevance to program priorities.
Matching requirements
This program has no statutory formula.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.
Examples of funded projects
Not Applicable.