Resource and Capacity Building to Advance the Science of Aggression across Species and Disciplines (R24 Clinical Trial Optional)

The Office of Behavioral and Social Sciences Research seeks to advance its mission by soliciting applications to advance research on the mechanisms of aggressive behavior across species and disciplines, consistent with OBSSR’s Congressional authorization to develop and coordinate research on violent behavior. Aggressive behavior is associated with numerous chronic diseases, especially psychiatric and neurological conditions. Additional scientific resources and capacity are needed to accelerate and enhance research to address this public health challenge through improved mechanistic understanding, prevention, and treatment of aggressive behavior. Priority areas for this NOFO will include: naturalistic and ecologically valid experimental paradigms that can be applied analogously across both animal and human research to bridge disciplinary silos and translational gaps; improved measurement tools to catalyze progress and improve causal inference, rigor, and reproducibility; and cross-species data repositories (e.g., behavioral, brain, genetic, and physiological data) to accelerate research advances to improve human health and well-being. Priority approaches will include: team science to promote innovation and collaboration across levels of analysis, disciplines, and the translational continuum; mentorship and career development to build a robust cohort of investigators; integrated bioethical perspectives; and outreach to and collaboration among researchers, practitioners, and patients to ensure use-inspired research with a strong foundational basis. Applications are not being solicited at this time. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R24 activity code. Investigators with expertise in neuroscience, psychology, evolutionary biology, behavioral genetics, sociology, criminology, ethics, and other related disciplines are encouraged to begin to consider applying for this new NOFO. Collaborative teams combining expertise in animal and human research will be encouraged.

Funding decisions are based on scientific merit (42 CFR 52h) and program relevance. Scientific merit review encompasses: the peer review criteria detailed in the specific funding announcement, as well as the significance, approach, and innovation of the proposed research; the competency of the principal investigator; the adequacy of the resources and environment; the proposed budget and requested period of support; and, where applicable, the adequacy of the measures for protecting against adverse effects upon humans, animals, or the environment.