Limited Competition: Tribal Institutional Review Board Establishment and Enhancement (TIRBEE)

The Tribal Institutional Review Board Establishment and Enhancement (TIRBEE) Notice of Funding Opportunity will enable federally-recognized Tribes or Tribal Entities to establish or enhance Institutional Review Boards. TIRBEE builds the capacity and infrastructure for biomedical research involving human participants in federally-recognized Tribal communities by expanding their Institutional Review Board review and oversight capabilities. This is a Forecast for a Limited Competition that will invite application(s) from eligible organization(s) to apply. Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered.

Other Eligible ApplicantsA federally-recognized AI/AN Tribe, as defined under 25 U.S.C. 1603(14); orA Tribal college or university, a Tribal health program, or a Tribal organization as defined under 25 U.S.C. 1603 (24), (25), and (26), respectively; orA consortium of two or more of those Tribal entities.Foreign Organizations/Foreign CollaborationsAn application may include foreign components only if one or more federally-recognized Tribes with ancestral catchment areas crossing the U. S. border will participate in the proposed Tribal Institutional Review Board Establishment and Enhancement (TIRBEE) application.

All accepted applications are reviewed for scientific and technical merit by an appropriate initial review group and by a national advisory council. The goal of NIGMS funding policies is to maximize the scientific impact of investments in investigator-initiated biomedical research to drive fundamental scientific discoveries that advance understanding of human health and disease. To address this goal, the Institute strives to support a broad portfolio of research grants of high scientific and technical merit, as determined by peer review, in its mission areas. However, in deciding to fund any application, NIGMS staff also considers other factors, including (consistent with applicable law): the breadth of the Institute�s research portfolio; approaches, and investigators; the total amount of funding available to the investigator; the priority of the research area for the Institute�s mission; Early-stage investigator status; At-risk investigator status?;? and whether the PI would have more than one NIGMS funded R01 (including multi-PI R01s). Because these factors are considered, NIGMS does not have a �payline� or strict cutoff in scores that it will fund. It is important to understand that even applications with outstanding scores might not be funded if the investigator already has substantial other support. Because NIGMS prioritizes funding for meritorious investigators who otherwise would not have support over providing additional grants to already well-funded...