OpenDue Jan 7, 2028
National Institutes of Health · Department of Health and Human Services
Integration of Imaging and Fluid-Based Tumor Monitoring in Cancer Therapy (R01 Clinical Trial Optional)
Open
· Opportunity PAR-25-175
· Assistance Listing 93.393, 93.395, 93.394
Key facts
- Deadline
- Due Jan 7, 2028 · 458 days left
- Award size
- Up to $500K
- Total available
- $500K
- Cost share / match ?
- Not required
- Who can apply
- Public college or university, Small business, Tribal government, Private college or university, City or town government, Nonprofit with 501(c)(3), Tribal organization, Other (see eligibility), Special district (utility, fire, etc.), Larger business, School district, Nonprofit without 501(c)(3), State government, County government
- Where
- Anywhere in the U.S., including Tennessee
Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account.
Registration is free but can take weeks, so start now, not when the deadline is close.
Grant-ready checklist
How this fits you
- ✓ Available in Tennessee (nationwide program)
- ✓ No cost share required
- i Tennessee recipients since 2023: 54
Tell us who you are to see whether you're eligible.
More from National Institutes of Health
Official notice: https://simpler.grants.gov/opportunity/ee1dd508-9138-4218-b055-8dbd8d2ee4ba · Printed from grantme.click/grants/3ebe3546-b02d-4ba2-93a3-15851cbf1d34
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About this grant
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) seeks research project (R01) grant applications describing projects that integrate imaging and fluid-based tumor monitoring (liquid biopsy) assays during cancer therapy in patients to determine the optimal use of those modalities in the characterization of therapy response and/or emergence of resistance.
Eligibility (from the notice)
Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Who in Tennessee has won this program
54 awards to Tennessee recipients in 3 counties since federal FY2023. Largest shown:
Past Tennessee recipients
| Recipient | Where | Amount | FY |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | $81.5M | 1993 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | $41.4M | 1999 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $14M | 2016 |
| Vanderbilt University | Nashville, Davidson County | $14M | 1997 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $12.8M | 2010 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $12.6M | 2014 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $11.1M | 1981 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $9.8M | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $8.6M | 2021 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | $6M | 2025 |
| Vanderbilt University | Nashville, Davidson County | $5.8M | 2005 |
| University Of Tennessee | Memphis, Shelby County | $5.3M | 2011 |
Source: USAspending.gov. Past awards show who this program funds; they don't guarantee future awards.
About the program (93.393)
Cancer Cause and Prevention Research
How applications are judged
The major elements in evaluating proposals include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; 2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific...
Matching requirements
This program has no statutory formula.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.
Examples of funded projects
Not Applicable.
Program listing on SAM.gov
About the program (93.394)
Cancer Detection and Diagnosis Research
How applications are judged
The major elements in evaluating proposals include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; 2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific...
Matching requirements
This program has no statutory formula.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.
Examples of funded projects
Not Applicable.
Program listing on SAM.gov
About the program (93.395)
Cancer Treatment Research
How applications are judged
The major elements in evaluating applications include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the...
Matching requirements
This program has no statutory formula.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.
Examples of funded projects
Not Applicable.
Program listing on SAM.gov
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