OpenDue Jan 7, 2028
National Institutes of Health · Department of Health and Human Services
Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21 Clinical Trial Optional)
Open
· Opportunity PAR-25-321
· Assistance Listing 93.395, 93.394, 93.399, 93.393, 93.396
Key facts
- Deadline
- Due Jan 7, 2028 · 458 days left
- Award size
- Not specified — see notice
- Cost share / match ?
- Not required
- Who can apply
- County government, Nonprofit with 501(c)(3), State government, Small business, Other (see eligibility), City or town government, School district, Special district (utility, fire, etc.), Public college or university, Tribal organization, Larger business, Private college or university, Nonprofit without 501(c)(3), Tribal government
- Where
- Anywhere in the U.S., including Tennessee
Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account.
Registration is free but can take weeks, so start now, not when the deadline is close.
Grant-ready checklist
How this fits you
- ✓ Available in Tennessee (nationwide program)
- ✓ No cost share required
- i Tennessee recipients since 2023: 80
Tell us who you are to see whether you're eligible.
More from National Institutes of Health
Official notice: https://simpler.grants.gov/opportunity/36fa146e-a461-4128-99a4-a65bc83aa928 · Printed from grantme.click/grants/1b7a88ef-7c2c-4bc1-97f1-70db3d362614
Read the official notice
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About this grant
Through this engineering-oriented Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to encourage submissions of exploratory/developmental Bioengineering Research Grant (EBRG) applications to demonstrate feasibility and potential utility of new capabilities or improvements in quality, speed, efficacy, operability, costs, and/or accessibility of solutions to problems in basic biomedical, pre-clinical, or clinical research, clinical care delivery, or accessibility.
Eligibility (from the notice)
Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Who in Tennessee has won this program
80 awards to Tennessee recipients in 3 counties since federal FY2023. Largest shown:
Past Tennessee recipients
| Recipient | Where | Amount | FY |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | $81.5M | 1993 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | $41.4M | 1999 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | $31.4M | 2003 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $25.8M | 2009 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $14M | 2016 |
| Vanderbilt University | Nashville, Davidson County | $14M | 1997 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $12.8M | 2010 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $12.6M | 2014 |
| Baptist Memorial Hospital-Tipton | Covington, Tipton County | $11.9M | 2014 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | $11.4M | 2017 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $11.1M | 1981 |
| Vanderbilt University | Nashville, Davidson County | $10.8M | 2020 |
Source: USAspending.gov. Past awards show who this program funds; they don't guarantee future awards.
About the program (93.393)
Cancer Cause and Prevention Research
How applications are judged
The major elements in evaluating proposals include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; 2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific...
Matching requirements
This program has no statutory formula.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.
Examples of funded projects
Not Applicable.
Program listing on SAM.gov
About the program (93.394)
Cancer Detection and Diagnosis Research
How applications are judged
The major elements in evaluating proposals include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; 2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific...
Matching requirements
This program has no statutory formula.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.
Examples of funded projects
Not Applicable.
Program listing on SAM.gov
About the program (93.395)
Cancer Treatment Research
How applications are judged
The major elements in evaluating applications include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the...
Matching requirements
This program has no statutory formula.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.
Examples of funded projects
Not Applicable.
Program listing on SAM.gov
About the program (93.396)
Cancer Biology Research
How applications are judged
The major elements in evaluating applications include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following will be considered in making funding decisions: 1) Scientific and technical merit of the proposed project as determined by scientific peer review; 2) Availability of funds; and 3) Relevance of the proposed project to program priorities.
Matching requirements
This program has no statutory formula.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.
Examples of funded projects
Not Applicable.
Program listing on SAM.gov
About the program (93.399)
Cancer Control — Cancer Control Grants
How applications are judged
The major elements in evaluating proposals include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives.
Matching requirements
This program has no statutory formula.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.
Examples of funded projects
Not Applicable.
Program listing on SAM.gov
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