National Institutes of Health · Department of Health and Human Services
Early-Onset Cancers: Investigating Etiology, Mechanisms, and Early Detection Strategies (RP1 Clinical Trials Optional)
In short: A grant from National Institutes of Health. Open to many kinds of groups. See who can apply.
Key facts
- Deadline
- The funder's estimated date (Oct 5, 2026) has passed. Check the official notice Estimate, not confirmed by the funder ?
- Award size
- Not stated: see the official notice
- Match ?
- Not required · Work out your budget and match
- Who can apply
- Larger business, City or town government, Tribal government, Private college or university, Tribal organization, Special district (utility, fire, etc.), Small business, Nonprofit with 501(c)(3), Nonprofit without 501(c)(3), County government, School district, Public college or university, State government, and others named in the official notice
- Where
- Anywhere in the U.S., including Tennessee
Opening soon: the funder has announced this grant, but you can't apply yet. Use the time to get ready and check whether it fits.
Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Get-ready checklist
How this fits you
- Available in Shelby County (nationwide program)
- No match required
- Past Tennessee awards on file: 225, including your county
Tell us who you are to see whether you're eligible.
About this grant
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications that investigate the etiology of sporadic non-hereditary early-onset cancers (EOCs: ages 18 to 49 years) and the underlying biological mechanisms that play a role in these cancers to inform prevention and control strategies. The proposed research is expected to advance the understanding of the unexplained rise of cancers in young adults. More specifically, studies should address one or more of the following: i) what modifiable exposures are driving the increase in the incidence of non-hereditary EOCs, and how do these factors vary by patient demographics? (ii) what biological mechanisms and host responses underly the increase in EOCs? and (iii) how can those at increased risk for developing EOCs be identified more effectively?
This NOFO consolidates exploratory/developmental and research project funding mechanisms to streamline the application process and sustain momentum in this critical research area. Applicants have the option of submitting either an exploratory/developmental research project with a project period of up to 2 years or a research project with a project period of 4 to 5 years.
Who can apply, from the official notice
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
Official notice: https://simpler.grants.gov/opportunity/e9757eee-7beb-4f2d-ab72-fe511b6c513c · Printed from grantme.click/grants/0a653074-d951-4499-9304-18130bed86ee
Writing the need statement? Shelby County facts with citations.
Who in Tennessee has won this program
50 awards to Tennessee groups in 3 counties since 1981 · 22 in Shelby County. Largest shown:
| Past winner | Where | Amount | Fiscal year |
|---|---|---|---|
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | $31.4M | 2003 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $25.8M | 2009 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $14.4M spent that year | 2025 |
| St. Jude Children's Research Hospital, Inc. | Memphis, Shelby County | $14.2M spent that year | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $14M | 2016 |
| Vanderbilt University | Nashville, Davidson County | $14M | 1997 |
| Baptist Memorial Hospital-Tipton | Covington, Tipton County | $11.9M | 2014 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | $11.4M | 2017 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $11.1M | 1981 |
| Vanderbilt University | Nashville, Davidson County | $10.8M | 2020 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | $10.5M | 2019 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $9.8M | 2023 |
Source: USAspending.gov; Federal Audit Clearinghouse. Past awards show who this program funds. They don't guarantee future awards.
Tennessee groups that got this money through a state agency or another organization
This federal money also reaches local groups as pass-through grants. 175 pass-through grants on file · 68 in Shelby County. Largest shown:
| Past winner | Where | Through | Amount | Fiscal year |
|---|---|---|---|---|
| Vanderbilt University Medical Center | Nashville, Davidson County | Health Research, Inc. | $1.3M | 2025 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | Ohio State University, the | $1M | 2023 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | Washington University, the | $1M | 2024 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Vanderbilt University | $1M | 2026 |
| Vanderbilt University | Nashville, Davidson County | Trustees of Dartmouth College | $780K | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Vanderbilt University | $732K | 2024 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Vanderbilt University | $729K | 2023 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | The General Hospital Corporation | $663K | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Ohio State University, the | $568K | 2024 |
| St. Jude Children's Research Hospital, Inc. | Memphis, Shelby County | The Washington University | $536K spent that year | 2025 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | The Regents of the University of Colorado | $533K | 2023 |
| Vanderbilt University | Nashville | Dartmouth College | $522K spent that year | 2025 |
Source: USAspending.gov pass-through reports (the first recipient reports each one of $30,000 or more).
More from National Institutes of Health
- Forecast to Renew the Notice of Funding Opportunity Announcement for the Multiple Chronic Disease Research Centers · The funder's estimated date (Jul 25, 2025) has passed. Check the official notice Estimate, not confirmed by the funder
- Forecast to Publish a Funding Opportunity Announcement for the Consortium on the Neurobiology of Adolescent Drinking in Adulthood (NADIA) Administrative Resource (Collaborative U24 - Clinical Trials not allowed) · The funder's estimated date (Sep 30, 2025) has passed. Check the official notice Estimate, not confirmed by the funder
- Forecast to Publish a Funding Opportunity Announcement for the Consortium on the Neurobiology of Adolescent Drinking in Adulthood (NADIA) Research Resource (Collaborative U24 - Clinical Trials not allowed) · The funder's estimated date (Sep 30, 2025) has passed. Check the official notice Estimate, not confirmed by the funder
- Alzheimer's Clinical Trials Consortium (ACTC) Clinical Trials · The funder's estimated date (Oct 5, 2025) has passed. Check the official notice Estimate, not confirmed by the funder
- Early- and Late-Stage Clinical Trials for the Spectrum of Alzheimer's Disease/Alzheimer's Disease-Related Dementias and Age-Related Cognitive Decline · The funder's estimated date (Oct 5, 2025) has passed. Check the official notice Estimate, not confirmed by the funder
- Research on System Support and Tools for Provider Training and Quality Monitoring for Suicide Preventive Care · The funder's estimated date (Oct 17, 2025) has passed. Check the official notice Estimate, not confirmed by the funder
About the federal program
Cancer Cause and Prevention Research
Program number 93.393 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Cooperative agreement (a grant with close agency involvement), project grant
How applications are judged
The major elements in evaluating proposals include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; 2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following criteria will be used in considering the scientific and technical merit of SBIR/STTR Phase I grant applications: (1) The soundness and technical merit of the proposed approach; (2) the qualifications of the proposed principal investigator, supporting staff, and consultants; (3) the technological innovation of the proposed research; (4) the potential of the proposed research for commercial application; (5) the appropriateness of the budget requested; (6) the adequacy and suitability of the facilities and research environment; and (7) where applicable, the adequacy of assurances detailing the proposed means for (a) safeguarding human or animal subjects, and/or (b) protecting against or minimizing any adverse effect on the environment. Phase II grant applications will be reviewed based upon the following criteria: (1) The degree to which the Phase I objectives were met and feasibility demonstrated; (2) the scientific...
Match
None required (federal program listing).
About the federal program
Cancer Biology Research
Program number 93.396 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Cooperative agreement (a grant with close agency involvement), project grant
How applications are judged
The major elements in evaluating applications include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives. The following will be considered in making funding decisions: 1) Scientific and technical merit of the proposed project as determined by scientific peer review; 2) Availability of funds; and 3) Relevance of the proposed project to program priorities.
Match
None required (federal program listing).
About the federal program
Cancer Control, also called “Cancer Control Grants”
Program number 93.399 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Project grant
How applications are judged
The major elements in evaluating proposals include assessments of: (1) The scientific merit and general significance of the proposed study and its objectives; (2) the technical adequacy of the experimental design and approach; (3) the competency of the proposed investigator or group to successfully pursue the project; (4) the adequacy of the available and proposed facilities and resources; (5) the necessity of the budget components requested in relation to the proposed project; and (6) the relevance and importance to announced program objectives.
Match
None required (federal program listing).