National Institutes of Health · Department of Health and Human Services
Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)
Key facts
- Deadline
- The funder's estimated date (Jul 15, 2025) has passed. Check the official notice Estimate, not confirmed by the funder ?
- Award size
- Not stated: see the official notice
- Total available
- $3M · about 5 awards
- Match ?
- Not required · Work out your budget and match
- Who can apply
- Small business, County government, Tribal organization, Tribal government, Public college or university, School district, Nonprofit with 501(c)(3), Private college or university, State government, and others named in the official notice
- Where
- Anywhere in the U.S., including Tennessee
Opening soon: the funder has announced this grant, but you can't apply yet. Use the time to get ready and check whether it fits.
Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Get-ready checklist
How this fits you
- Available in Madison County (nationwide program)
- No match required
- Past Tennessee awards on file: 72
Tell us who you are to see whether you're eligible.
Official notice: https://simpler.grants.gov/opportunity/6c6417e0-a321-48cd-a93d-8dce887d6b55 · Printed from grantme.click/grants/0057ddb5-5134-4021-983a-5f7b4bc0c30b
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About this grant
The National Human Genome Research Institute (NHGRI) intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications for research to characterize genomic variation to assess the impact of individual variants on genome function. This will be accomplished by systematically perturbing variants or elements using one or more high-throughput methods; collecting data on the effects of variants in DNA, RNA, or protein-coding elements on molecular, cellular, or organismal phenotypes; and developing robust, reproducible, and portable data processing pipelines. Centers funded through this initiative will become a part of the Impact of Genomic Variation on Function (IGVF) Consortium. As consortium members, centers will work together to ensure all consortium resources are accessible to a wide variety of potential users. Centers are also expected to collaborate with other consortium components to coordinate assays, variants, and cell types, and to develop shared analysis strategies to meet consortium goals.
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
The NOFO is expected to be published in 2025 with an expected application due date in 2025.
This NOFO will utilize the UM1 activity code. Details of the planned NOFO are provided below.
Writing the need statement? Madison County facts with citations.
Who in Tennessee has won this program
28 awards to Tennessee groups in 2 counties since 2016 · 0 in Madison County. Largest shown:
| Past winner | Where | Amount | Fiscal year |
|---|---|---|---|
| Vanderbilt University Medical Center | Nashville, Davidson County | $16.8M | 2020 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $13.3M spent that year | 2025 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $8.1M | 2016 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $8M | 2018 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $7M | 2020 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | $5.2M | 2018 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.6M | 2022 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.5M | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.4M | 2024 |
| Vanderbilt University | Nashville, Davidson County | $4.3M | 2016 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.3M | 2022 |
| Meharry Medical College | Nashville, Davidson County | $4.2M | 2023 |
Source: USAspending.gov, Federal Audit Clearinghouse. Past awards show who this program funds. They don't guarantee future awards.
Tennessee groups that got this money through a state agency or another organization
This federal money also reaches local groups as pass-through grants. 44 pass-through grants on file · 0 in Madison County. Largest shown:
| Past winner | Where | Through | Amount | Fiscal year |
|---|---|---|---|---|
| Vanderbilt University | Nashville, Davidson County | Vanderbilt University Medical Center | $2.3M | 2023 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | Weill Medical College of Cornell University | $2.1M | 2026 |
| Vanderbilt University Medical Center | Nashville, Davidson County | University of Alabama at Birmingham | $1.5M | 2026 |
| Meharry Medical College | Nashville, Davidson County | Vanderbilt University Medical Center | $1.1M | 2023 |
| Meharry Medical College | Nashville, Davidson County | Vumc | $813K spent that year | 2023 |
| St. Jude Children's Research Hospital, Inc. | Memphis, Shelby County | Cornell University | $698K spent that year | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | University of North Carolina at Chapel Hill | $669K | 2023 |
| Meharry Medical College | Nashville, Davidson County | Vanderbilt University Medical Center | $545K | 2023 |
| Meharry Medical College | Nashville, Davidson County | Vanderbilt University Medical Center | $536K | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | Broad Institute of Mit and Harvard | $455K spent that year | 2025 |
| St Jude Children's Research Hospital Inc | Memphis, Shelby County | The Leland Stanford Junior University | $444K | 2024 |
| St. Jude Children's Research Hospital, Inc. | Memphis, Shelby County | Stanford University | $432K spent that year | 2025 |
Source: USAspending.gov pass-through reports (the first recipient reports each one of $30,000 or more).
About the federal program
Human Genome Research, also called “National Human Genome Research Institute”
Program number 93.172 (the federal Assistance Listing number) · U.S. Department of Health and Human Services, National Institutes of Health · Project grant
How applications are judged
In each year's official notice: read this year's.
Match
None required (federal program listing).
Examples of funded projects
Fiscal year 2025: Examples of research supported by NHGRI in FY 2025 include characterization of genes, sequencing, databases, and projects on the following list: https://reporter.nih.gov/search/KP6XtPborUWv7kYNeFlJSA/projects?shared=true
Fiscal year 2026: Current projects supported by NHGRI include basic genomic science; functional and clinical variation; genomic medicine; technology development; computational genomics and data science; training programs; conferences; databases; determining the ethical, legal, and social implications (ELSI) of biomedical and behavioral research; as well as projects on the following list:
https://reporter.nih.gov/search/PbojAWqEZ0aySDrGRZXHTg/projects?shared=true