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Defense Threat Reduction Agency · Department of Defense

Fundamental Research to Counter Weapons of Mass Destruction

Open · Opportunity HDTRA1-25-S-0001 · Assistance Listing 12.351

Key facts

Deadline
Due Sep 30, 2034 · 2915 days left
Award size
Not specified — see notice
Total available
$500M · about 10 awards
Cost share / match ?
Not required · Work out your budget and match
Who can apply
Anyone (unrestricted)
Where
Anywhere in the U.S., including Tennessee

Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Grant-ready checklist

How this fits you

  • Available in Tennessee (nationwide program)
  • No cost share required
  • Past Tennessee awards on file: 18

Tell us who you are to see whether you're eligible.

Read the official notice View on Grants.gov Add deadline to my calendar Sign in to save

About this grant

** Fundamental Research BAA Amendment 2 posted on January 15, 2026** This Amendment adds Topics B1-B6. PRE-APPLICATION WHITE PAPERS FOR THIS TOPIC MUST BE SUBMITTED BY 11:59 PM (MIDNIGHT) EST ON 2 MARCH 2026. White papers may not be considered if they are received after this deadline. Potential applicants are strongly encouraged to review the BAA in its entirety. **Please note that ALL general correspondence for this BAA must be sent to dtra.belvoir.rd.mbx.rd-cb-frbaa25-34-a@mail.mil Thrust Area-specific correspondence must be sent to dtra.belvoir.rd.mbx.rd-cb-frbaa25-34-a@mail.mil

Eligibility (from the notice)

See Section 3. “Eligibility Information”, of the BAA for full Eligibility Requirements.

Should we apply? (2-minute check) Ask a partner for a letter

Your schedule, working back from the deadline

  1. Oct7
    Check that your SAM.gov registration is active (or start it now)
    Grants.gov: allow up to 10 business days for SAM registration, weeks or months if information isn't verified. It must be renewed every year. Grants.gov
  2. Sep9
    Ask partners for letters of support or commitment
    Suggested: partners need about three weeks to write and sign letters.
  3. Sep25
    Finish a complete draft for a final review
    Suggested: leave about a week for someone else to read the draft.
  4. Sep28
    Submit
    Grants.gov: submit at least 24–48 hours before the deadline: uploads fail, systems slow down, errors need fixing. Grants.gov blog
  5. Sep30
    Deadline
    From the funder.

Save this grant to put these dates in your tracker and private calendar.

What the official notice requires

Pulled from the funding notice HDTRA125S0001_BTopicsRelease_Final_V2.pdf (60 pages) so you can see the requirements at a glance. Each item shows the notice's own words; open the page to read it in context. The notice itself always controls.

Award size and project length

  • Award amounts here are per year · p. 4
    “Grants may range from small dollar value (e.g., $25K) up to $1M annually (total, including both direct and indirect costs) depending on the nature and the scope of work.” Open page 4

Registrations you need first

  • SAM.gov · p. 6
    “This BAA, in addition to any amendments issued in conjunction with this BAA, will be posted to the Grant Opportunities Website (https://www.grants.gov) and the System for Award Management website (https://sam.gov/).Applicants are responsible for monitoring…” Open page 6
  • Grants.gov · p. 13
    “Block 4c – Previous Grants.gov Tracking ID.” Open page 13
  • Unique Entity ID (UEI) · p. 21
    “All organizations applying online through Grants.gov must register with the SAM and will receive a unique entity identifier (UEI) number.” Open page 21

New to these? SAM.gov registration can take weeks, so start early: grant-ready checklist.

Steps before the deadline

  • Pre-application · p. 4
    “All submissions (pre-application white papers and invited proposals) must be made in accordance with the submission instructions in this BAA through www.grants.gov using the application packages linked with this BAA (under the “Package” tab) on www.grants.gov.” Open page 4
  • Pre-application · p. 9
    “Federal laboratories (including DoD and DOE) and FFRDCs are eligible to submit abstracts (when required), pre-application white papers, and proposals in response to the Government Call (HDTRA1-25-34-FRCWMD-Call).” Open page 9
  • Pre-application · p. 10
    “This announcement contains all information required to submit a pre-application white paper and invited proposal.” Open page 10
  • Pre-application · p. 10
    “The required application packages for the pre-application white papers and for the invited proposals are posted with this announcement.” Open page 10

What to submit

  • Project abstract or summary · p. 3
    “If the submission is not feasible within this 45 calendar day window, the abstract must be coordinated again to ensure the interest in the white paper remains.” Open page 3
  • Form SF-424 · p. 10
    “Form Name Phase I Pre-Application White Paper Phase II Invited Proposal SF-424 (R&R) Application for Federal Assistance Form Required Required RR Budget Form N/A Required R&R Subaward Budget Attachment(s) Form(s) N/A If Applicable Research & Related…” Open page 10
  • Form SF-LLL · p. 10
    “Form Name Phase I Pre-Application White Paper Phase II Invited Proposal SF-424 (R&R) Application for Federal Assistance Form Required Required RR Budget Form N/A Required R&R Subaward Budget Attachment(s) Form(s) N/A If Applicable Research & Related…” Open page 10
  • Budget narrative / justification · p. 15
    “Applicants are required to submit a budget justification.” Open page 15
  • Resumes or bios of key staff · p. 16
    “A biographical sketch is required for each PI and Co-PI on the project.” Open page 16

Length limits

  • References: 4 pages max · p. 12
    “References may be included within the 4-page limit at the discretion of the applicant; however, extensive references are not required.” Open page 12
  • Page limit (see quote): 1 page max · p. 16
    “DTRA does not have a preference for the format of the biographical sketch; however, it should be limited to 1 page per person.” Open page 16
  • Page limit (see quote): 20 pages max · p. 17
    “The uploaded technical proposal must not exceed 20 pages (including references).” Open page 17

Formatting rules

  • 12-point font, 1-inch margins, single-spaced · p. 12
    “A page is defined as 8 ½ x 11 inches, single-spaced, with one-inch margins in type not smaller than 12 point Times New Roman font.” Open page 12

Cost share or match

  • Cost share / match · p. 9
    “In general, cost sharing or matching is not required for applications to this announcement.” Open page 9

Mistakes that get applications rejected

  • Sent the wrong way or format · p. 12
    “Hard copies or email attachments of applications will not be accepted.” Open page 12
  • Could get your application rejected · p. 20
    “Movie and sound file attachments will not be accepted.” Open page 20
  • Sent the wrong way or format · p. 24
    “Any criterion scored as “Unacceptable (U)” will render the pre-application white paper “Not Selectable,” and the pre-application white paper will not be considered further.” Open page 24
  • Could get your application rejected · p. 24
    “Any criterion scored as “Unacceptable (U)” will render the proposal “Not Selectable,” and the proposal will not be considered further.” Open page 24
  • Sent the wrong way or format · p. 46
    “Pre- application white papers and proposals that outline scope and effort for different base period and option combinations may also be considered; however, note that pre-application whitepapers and proposals that outline scope and effort that exceed a total…” Open page 46
  • Sent the wrong way or format · p. 54
    “Pre-application white papers and proposals that outline scope and effort for different base period and option combinations may also be considered; however, note that pre-application white papers and proposals that outline scope and effort that exceed a total…” Open page 54

Who in Tennessee has won this program

4 awards to Tennessee recipients in 2 counties since 2012. Largest shown:

Past Tennessee recipients
RecipientWhereAmountFY
Vanderbilt UniversityNashville, Davidson County$4.3M2017
Vanderbilt UniversityNashville, Davidson County$3M2018
University Of TennesseeKnoxville, Knox County$1.7M2018
Vanderbilt UniversityNashville, Davidson County$1.7M2013

Source: USAspending.gov. Past awards show who this program funds; they don't guarantee future awards.

Tennessee groups that got this money through a state agency or another grantee

This federal money also reaches local groups as subawards. 14 subawards on file. Largest shown:

Tennessee subaward recipients
RecipientWhereThroughAmountFY
Vanderbilt UniversityNashville, Davidson CountyPennsylvania State University, the$3.3M2026
Vanderbilt UniversityNashville, Davidson CountyPennsylvania State University, the$3M2026
Vanderbilt UniversityNashville, Davidson CountyPennsylvania State University, the$2.7M2025
Vanderbilt UniversityNashville, Davidson CountyPennsylvania State University, the$2M2025
Fisk UniversityNashville, Davidson CountyPennsylvania State University, the$1.1M2026
Fisk UniversityNashville, Davidson CountyPennsylvania State University, the$1.1M2026
Fisk UniversityNashville, Davidson CountyPennsylvania State University, the$983K2026
Fisk UniversityNashville, Davidson CountyPennsylvania State University, the$925K2025
Fisk UniversityNashville, Davidson CountyPennsylvania State University, the$872K2025
Fisk UniversityNashville, Davidson CountyPennsylvania State University, the$751K2024
Vanderbilt UniversityNashville, Davidson CountyPennsylvania State University, the$742K2023
Fisk UniversityNashville, Davidson CountyPennsylvania State University, the$564K2023

Source: USAspending.gov subaward reports (prime recipients report subawards of $30,000 or more).

About the program (12.351)

Scientific Research - Combating Weapons of Mass Destruction

How applications are judged

Generally, the principal evaluation and selection criteria are the technical or socio-economic merits of the proposal and potential long term contributions of DTRA's specific mission. Other selection criteria vary with the nature of the specific research or research-related activity. Typically, these include the qualifications, capabilities, and experience of the proposed Principal Investigator and/or key personnel who are critical in achieving the proposal objectives; adequacy of current or planned facilities, and equipment; and reasonableness and realism of the proposed costs.

Matching requirements

Statutory Formula: Title Code of Federal Regulations - Financial, Part 200, Subpart N/A,Public Law N/A.N/AMatching requirements are not applicable to this assistance listing. MOE requirements are not applicable to this assistance listing.

Examples of funded projects

Fiscal Year2024: Option exercises: Exercised one option on an active Epipointe LLC grant, �One Health Surveillance Approach Focusing on High-Risk Occupations to Identify Hotspots of Zoonoses in India�, which was then cancelled in August 2025. This grant aimed to support the Biological Threat Reduction Program (BTRP) mission to protect the United States and its Armed Forces from biological threats by strengthening the capabilities of partner nations to prevent, detect, and prepare for the threat of biological weapons use by an adversary.Fiscal Year2025: Continues to fund ongoing research projects in fundamental research as well as two cooperative agreements that encompass a consortia of universities. Research was performed in both medical and physical sciences including a deep machine-learning guided approach has resulted in five new antibiotics against antimicrobial resistance as well as a highly adaptable experimental model system capable of storing the energy of natural light to efficiently decompose chemical warfare agents in the dark and under ambient conditions. Research also furthered support of the Biological Threat Reduction Program mission to strengthen the...

Program listing on SAM.gov

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