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U.S. National Science Foundation

Mathematical Foundations of Artificial Intelligence (MFAI)

Open · Opportunity 24-569 · Assistance Listing 47.075, 47.049, 47.041, 47.070

Key facts

Deadline
Due Oct 9, 2026 · 3 days left
Award size
$500K – $1.5M
Total available
$8.5M
Cost share / match
Not required
Who can apply
Other (see eligibility)
Where
Anywhere in the U.S., including Tennessee

Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. The deadline is in 3 days. If your registration isn't already active, it may not be ready in time, so check it today. Grant-ready checklist

How this fits you

  • Available in Tennessee (nationwide program)
  • No cost share required
  • Only 3 days left to apply
  • Tennessee recipients since 2023: 81

Tell us who you are to see whether you're eligible.

Read the official notice View on Grants.gov Add deadline to my calendar

About this grant

Machine Learning and Artificial Intelligence (AI) are enabling extraordinary scientific breakthroughs in fields ranging from protein folding, natural language processing, drug synthesis, and recommender systems to the discovery of novel engineering materials and products. These achievements lie at the confluence of mathematics, statistics, engineering and computer science, yet a clear explanation of the remarkable power and also the limitations of such AI systems has eluded scientists from all disciplines. Critical foundational gaps remain that, if not properly addressed, will soon limit advances in machine learning, curbing progress in artificial intelligence. It appears increasingly unlikely that these critical gaps can be surmounted with increased computational power and experimentation alone. Deeper mathematical understanding is essential to ensuring that AI can be harnessed to meet the future needs of society and enable broad scientific discovery, while forestalling the unintended consequences of a disruptive technology. The National Science Foundation Directorates for Mathematical and Physical Sciences (MPS), Computer and Information Science and Engineering (CISE), Engineering (ENG), and Social, Behavioral and Economic Sciences (SBE) will jointly sponsor research collaborations consisting of mathematicians, statisticians, computer scientists, engineers, and social and behavioral scientists focused on the mathematical and theoretical foundations of AI. Research activities should focus on the most challenging mathematical and theoretical questions aimed at understanding the capabilities, limitations, and emerging properties of AI methods as well as the development of novel, and mathematically grounded, design and analysis principles for the current and next generation of AI approaches. Specific research goals include: establishing a fundamental mathematical understanding of the factors determining the capabilities and limitations of current and emerging generations of AI systems, including, but not limited to, foundation models, generative models, deep learning, statistical learning, federated learning, and other evolving paradigms; the development of mathematically grounded design and analysis principles for the current and next generations of AI systems; rigorous approaches for characterizing and validating machine learning algorithms and their...

Eligibility (from the notice)

*Who May Submit Proposals: Proposals may only be submitted by the following: -Non-profit, non-academic organizations: Independent museums, observatories, research laboratories, professional societies and similar organizations located in the U.S. that are directly associated with educational or research activities. -Institutions of Higher Education (IHEs) - Two- and four-year IHEs (including community colleges) accredited in, and having a campus located in the US, acting on behalf of their faculty members. *Who May Serve as PI: As of the date the proposal is submitted, any PI, co-PI, or senior/key personnel must hold either: a tenured or tenure-track position, or a primary, full-time, paid appointment in a research or teaching position at a US-based campus of an organization eligible to submit to this solicitation (see above), with exceptions granted for family or medical leave, as determined by the submitting organization. Individuals with primary appointments at for-profit non-academic organizations or at overseas branch campuses of U.S. institutions of higher education are not eligible.

Who in Tennessee has won this program

81 awards to Tennessee recipients in 5 counties since federal FY2023. Largest shown:

Past Tennessee recipients
RecipientWhereAmountFY
University Of TennesseeKnoxville, Knox County$11.7M2023
University Of TennesseeKnoxville, Knox County$9M2026
Vanderbilt UniversityNashville, Davidson County$4M2025
Vanderbilt UniversityNashville, Davidson County$3.2M2022
Vanderbilt UniversityNashville, Davidson County$3M2024
University Of TennesseeKnoxville, Knox County$2.8M2022
University Of MemphisMemphis, Shelby County$2.6M2019
University Of TennesseeKnoxville, Knox County$2.4M2021
Vanderbilt UniversityNashville, Davidson County$2.2M2023
University Of TennesseeKnoxville, Knox County$2.1M2023
University Of TennesseeKnoxville, Knox County$2M2024
University Of TennesseeKnoxville, Knox County$2M2020

Source: USAspending.gov. Past awards show who this program funds; they don't guarantee future awards.

About the program (47.041)

Engineering — (ENG)

How applications are judged

Not Applicable.

Matching requirements

This program has no statutory formula. Matching requirements are not applicable to this assistance listing. MOE requirements are not applicable to this assistance listing.

Examples of funded projects

Not Applicable.

Program listing on SAM.gov

About the program (47.049)

Mathematical and Physical Sciences — (MPS)

How applications are judged

Not Applicable.

Matching requirements

This program has no statutory formula. Matching requirements are not applicable to this assistance listing. MOE requirements are not applicable to this assistance listing.

Examples of funded projects

Not Applicable.

Program listing on SAM.gov

About the program (47.070)

Computer and Information Science and Engineering — (CISE)

How applications are judged

Not Applicable.

Matching requirements

This program has no statutory formula. Matching requirements are not applicable to this assistance listing. MOE requirements are not applicable to this assistance listing.

Examples of funded projects

Not Applicable.

Program listing on SAM.gov

About the program (47.075)

Social, Behavioral, and Economic Sciences — (SBE)

How applications are judged

Not Applicable.

Matching requirements

This program has no statutory formula. Matching requirements are not applicable to this assistance listing. MOE requirements are not applicable to this assistance listing.

Examples of funded projects

Not Applicable.

Program listing on SAM.gov

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