National Institutes of Health · Department of Health and Human Services
Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)
Key facts
- Deadline
- Forecast — the expected date (Aug 22, 2025) has passed; watch for the official notice
- Award size
- Not specified — see notice
- Total available
- $10M · about 5 awards
- Cost share / match ?
- Not required
- Who can apply
- Other (see eligibility), State government, Tribal organization, Tribal government, Nonprofit with 501(c)(3), Private college or university, School district, County government, Public college or university, Larger business, Small business
- Where
- Anywhere in the U.S., including Tennessee
Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Grant-ready checklist
How this fits you
- Available in Gibson County (nationwide program)
- No cost share required
- Tennessee recipients since 2023: 23
Tell us who you are to see whether you're eligible.
More from National Institutes of Health
- Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed) · Forecast — the expected date (Jul 15, 2025) has passed; watch for the official notice
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- Forecast to Renew the Notice of Funding Opportunity Announcement for the Multiple Chronic Disease Research Centers · Forecast — the expected date (Jul 25, 2025) has passed; watch for the official notice
- Forecast to Publish a Funding Opportunity Announcement for the Consortium on the Neurobiology of Adolescent Drinking in Adulthood (NADIA) Administrative Resource (Collaborative U24 - Clinical Trials not allowed) · Forecast — the expected date (Sep 30, 2025) has passed; watch for the official notice
- Forecast to Publish a Funding Opportunity Announcement for the Consortium on the Neurobiology of Adolescent Drinking in Adulthood (NADIA) Research Resource (Collaborative U24 - Clinical Trials not allowed) · Forecast — the expected date (Sep 30, 2025) has passed; watch for the official notice
- Alzheimer's Clinical Trials Consortium (ACTC) Clinical Trials · Forecast — the expected date (Oct 5, 2025) has passed; watch for the official notice
Official notice: https://simpler.grants.gov/opportunity/e0071a8f-bde5-444a-bd22-f6e7bce40345 · Printed from grantme.click/grants/4fad2ead-2f52-45cf-a43c-5609e6b35b35
Read the official notice View on Grants.gov Sign in to save
About this grant
The National Human Genome Research Institute (NHGRI) intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications to study the effects of genetic or environmental interactions on genomic variant impact. To accomplish this, centers funded through this initiative will propose a research framework to investigate whether interactions, with effects beyond additive, are important modifiers of the impact of variants. Centers will apply their framework to experimentally test combinations for interactions. The rationale for this research is the identification of a structure within the interaction landscape might result in better predictions of the most important interactions to test, leading to more effective variant testing, better understanding of Genome-wide Association Studies (GWAS), and improved polygenic scores. As IGVF Consortium members, centers will work together to ensure all consortium resources are accessible to a wide variety of potential users. Centers are also expected to collaborate with other consortium components to coordinate assays, variants, and cell types, and to develop shared analysis strategies to meet consortium goals.
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in 2025 with an expected application due date in 2025. This NOFO will utilize the UM1 activity code.
Eligibility (from the notice)
Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply; Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply; Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Who in Tennessee has won this program
23 awards to Tennessee recipients in 2 counties since federal FY2023 · 0 in Gibson County. Largest shown:
| Recipient | Where | Amount | FY |
|---|---|---|---|
| Vanderbilt University Medical Center | Nashville, Davidson County | $16.8M | 2020 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $8.1M | 2016 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $8M | 2018 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $7M | 2020 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | $5.2M | 2018 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.6M | 2022 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.5M | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.4M | 2024 |
| Vanderbilt University | Nashville, Davidson County | $4.3M | 2016 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.3M | 2022 |
| Meharry Medical College | Nashville, Davidson County | $4.2M | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $3.3M | 2017 |
Source: USAspending.gov. Past awards show who this program funds; they don't guarantee future awards.
About the program (93.172)
Human Genome Research — National Human Genome Research Institute
How applications are judged
Criteria for selecting proposals is described at the NOFO level.
Matching requirements
This program has no statutory formula.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.
Examples of funded projects
Fiscal Year2025: Examples of research supported by NHGRI in FY 2025 include characterization of genes, sequencing, databases, and projects on the following list: https://reporter.nih.gov/search/KP6XtPborUWv7kYNeFlJSA/projects?shared=trueFiscal Year2026: Current projects supported by NHGRI include basic genomic science; functional and clinical variation; genomic medicine; technology development; computational genomics and data science; training programs; conferences; databases; determining the ethical, legal, and social implications (ELSI) of biomedical and behavioral research; as well as projects on the following list:
https://reporter.nih.gov/search/PbojAWqEZ0aySDrGRZXHTg/projects?shared=true