National Institutes of Health · Department of Health and Human Services
Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)
Key facts
- Deadline
- Forecast — the expected date (Jul 15, 2025) has passed; watch for the official notice
- Award size
- Not specified — see notice
- Total available
- $3M · about 5 awards
- Cost share / match ?
- Not required · Work out your budget and match
- Who can apply
- Small business, Other (see eligibility), County government, Tribal organization, Tribal government, Public college or university, School district, Nonprofit with 501(c)(3), Private college or university, State government
- Where
- Anywhere in the U.S., including Tennessee
Before you apply: federal grants require an active SAM.gov registration (Unique Entity ID) and a Grants.gov account. Registration is free but can take weeks, so start now, not when the deadline is close. Grant-ready checklist
How this fits you
- Open to: Nonprofit with 501(c)(3)
- Available in Rutherford County (nationwide program)
- No cost share required
- Past Tennessee awards on file: 45
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Official notice: https://simpler.grants.gov/opportunity/6c6417e0-a321-48cd-a93d-8dce887d6b55 · Printed from grantme.click/grants/0057ddb5-5134-4021-983a-5f7b4bc0c30b
Read the official notice View on Grants.gov Sign in to save
About this grant
The National Human Genome Research Institute (NHGRI) intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications for research to characterize genomic variation to assess the impact of individual variants on genome function. This will be accomplished by systematically perturbing variants or elements using one or more high-throughput methods; collecting data on the effects of variants in DNA, RNA, or protein-coding elements on molecular, cellular, or organismal phenotypes; and developing robust, reproducible, and portable data processing pipelines. Centers funded through this initiative will become a part of the Impact of Genomic Variation on Function (IGVF) Consortium. As consortium members, centers will work together to ensure all consortium resources are accessible to a wide variety of potential users. Centers are also expected to collaborate with other consortium components to coordinate assays, variants, and cell types, and to develop shared analysis strategies to meet consortium goals.
This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.
The NOFO is expected to be published in 2025 with an expected application due date in 2025.
This NOFO will utilize the UM1 activity code. Details of the planned NOFO are provided below.
Should we apply? (2-minute check) Ask a partner for a letter
Writing the need statement? Rutherford County facts with citations.
Who in Tennessee has won this program
23 awards to Tennessee recipients in 2 counties since 2016 · 0 in Rutherford County. Largest shown:
| Recipient | Where | Amount | FY |
|---|---|---|---|
| Vanderbilt University Medical Center | Nashville, Davidson County | $16.8M | 2020 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $8.1M | 2016 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $8M | 2018 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $7M | 2020 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | $5.2M | 2018 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.6M | 2022 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.5M | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.4M | 2024 |
| Vanderbilt University | Nashville, Davidson County | $4.3M | 2016 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $4.3M | 2022 |
| Meharry Medical College | Nashville, Davidson County | $4.2M | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | $3.3M | 2017 |
Source: USAspending.gov. Past awards show who this program funds; they don't guarantee future awards.
Tennessee groups that got this money through a state agency or another grantee
This federal money also reaches local groups as subawards. 22 subawards on file · 0 in Rutherford County. Largest shown:
| Recipient | Where | Through | Amount | FY |
|---|---|---|---|---|
| Vanderbilt University | Nashville, Davidson County | Vanderbilt University Medical Center | $2.3M | 2023 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | Weill Medical College of Cornell University | $2.1M | 2026 |
| Vanderbilt University Medical Center | Nashville, Davidson County | University of Alabama At Birmingham | $1.5M | 2026 |
| Meharry Medical College | Nashville, Davidson County | Vanderbilt University Medical Center | $1.1M | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | University of North Carolina At Chapel Hill | $669K | 2023 |
| Meharry Medical College | Nashville, Davidson County | Vanderbilt University Medical Center | $545K | 2023 |
| Meharry Medical College | Nashville, Davidson County | Vanderbilt University Medical Center | $536K | 2023 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | The Leland Stanford Junior University | $444K | 2024 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | The Leland Stanford Junior University | $424K | 2026 |
| St Jude Children'S Research Hospital Inc | Memphis, Shelby County | The Leland Stanford Junior University | $424K | 2025 |
| Vanderbilt University | Nashville, Davidson County | Vanderbilt University Medical Center | $395K | 2023 |
| Vanderbilt University Medical Center | Nashville, Davidson County | The Broad Institute, Inc | $379K | 2024 |
Source: USAspending.gov subaward reports (prime recipients report subawards of $30,000 or more).
About the program (93.172)
Human Genome Research — National Human Genome Research Institute
How applications are judged
Criteria for selecting proposals is described at the NOFO level.
Matching requirements
This program has no statutory formula.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.
Examples of funded projects
Fiscal Year2025: Examples of research supported by NHGRI in FY 2025 include characterization of genes, sequencing, databases, and projects on the following list: https://reporter.nih.gov/search/KP6XtPborUWv7kYNeFlJSA/projects?shared=trueFiscal Year2026: Current projects supported by NHGRI include basic genomic science; functional and clinical variation; genomic medicine; technology development; computational genomics and data science; training programs; conferences; databases; determining the ethical, legal, and social implications (ELSI) of biomedical and behavioral research; as well as projects on the following list:
https://reporter.nih.gov/search/PbojAWqEZ0aySDrGRZXHTg/projects?shared=true